Synthesis and Anticonvulsant Studies of Thiazolidinone and Azetidinone Derivatives from Indole Moiety

Sachin Saini; Archana

doi:10.1055/a-0809-5098

Drug Research, Table of Contents

Drug Res (Stuttg) 2019; 69(08): 445-450
DOI: 10.1055/a-0809-5098

Original Article

Synthesis and Anticonvulsant Studies of Thiazolidinone and Azetidinone Derivatives from Indole Moiety

Authors

Archana

Sachin Saini

²Research Scholar, Department of Chemistry, Mewar University, Rajasthan, India

Abstract

2-Amino-5-(3’-indolomethylene)-1, 3 , 4 - oxadiazole (3) undergoes facile condensation with various aromatic aldehydes to gave 2-substitiuted arylidenylamino-5-(3’- indolomethylene) – 1, 3 , 4 – oxadiazole (4–8). Cyclocondensation of (4–8) with thioglycolic acid and triethylamine yielded 3-[5’-(3”- indolomethylene)- 1’, 3’, 4’- oxadiazol-2’-yl]- 2- (substituted aryl)-4- thiazolidinones (9–13) and 1-[5’-(3”- indolomethylene) -1’, 3’, 4’- oxadiazol - 2’- yl ] -4-(substituted aryl) -2- azetidinones (14–18). The structures of these compounds were established on the basis of analytical and spectral data. The newly synthesised compounds were evaluated for their anticonvulsant activity and acute toxicity.

Key words

Indolyl oxadiazole - indolyl thazolidinones - indolyl azetidinones - spectral studies - anticonvulsant activity - acute toxicity

Full Text

References

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