Fundusautofluoreszenz: Klinische Anwendung und diagnostische Bedeutung

Zusammenfassung

Die Bildgebung mittels Fundusautofluoreszenz (FAF) ist ein nichtinvasives Verfahren, das Fluorophore vor allem auf Ebene der Fotorezeptoren, des Subretinalraums und des retinalen Pigmentepithels sichtbar macht und zusätzliche, wichtige Informationen liefert. Sie hat entscheidend zum pathophysiologischen Verständnis vieler Erkrankungen beigetragen und wird in Kombination mit anderen bildgebenden Verfahren u. a. für Diagnostik und Verlaufsbeobachtung eingesetzt.

Abstract

Non-invasive fundus autofluorescence (FAF) imaging visualizes fluorophores at the level of the photoreceptors, the subneurosensory space and the retinal pigment epithelium. It gives important information over and above other imaging techniques. FAF imaging has improved the pathophysiological understanding of various retinal diseases. In combination with fundus photography, fluorescence angiography, optical coherence tomography, and electrophysiological examinations, FAF imaging is useful with regard to diagnostics and monitoring both during the natural course and after therapies. This review highlights basic principles of FAF and its clinical application in various retinal diseases.

Schlüsselwörter

Fundusautofluoreszenz - Lipofuszin - konfokale Scanning-Laser-Ophthalmoskopie - altersabhängige Makuladegeneration - Netzhautdystrophie

Key words

fundus autofluorescence - lipofuscin - confocal scanning laser ophthalmoscopy - age-related macular degeneration - retinal dystrophies

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