Precision Surgery for Pheochromocytomas and Paragangliomas

Douglas Wiseman; Mustapha El Lakis; Naris Nilubol

doi:10.1055/a-0926-3618

Hormone and Metabolic Research, Table of Contents

Horm Metab Res 2019; 51(07): 470-482
DOI: 10.1055/a-0926-3618

Review

Precision Surgery for Pheochromocytomas and Paragangliomas

Douglas Wiseman

¹Surgical Oncology Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA

,

Mustapha El Lakis

¹Surgical Oncology Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA

,

Naris Nilubol

¹Surgical Oncology Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA

› Author Affiliations

Abstract

Since Felix Fränkel’s account of pheochromocytoma in 1886, great discoveries and vast advancements in the diagnosis, genetics, anatomical and functional imaging techniques, and surgical management of pheochromcytoma and paraganglioma (P-PGL) have been made. The improved insight in the pathophysiology of P-PGL and more accurate detection methods enable physicians to tailor the treatment plan to an individual based on the genetic profile and tumor behavior. This review will cover briefly the clinical features, diagnosis, genetic mutations, and imaging modalities that are used to guide current surgical management of these rare and interesting endocrinopathies.

Key words

pheochromocytoma - paraganglioma - precision surgery - clusters - biochemical phenotypes - genetic testing - anatomic and functional imaging

Full Text

References

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