Exp Clin Endocrinol Diabetes 2021; 129(08): 553-559
DOI: 10.1055/a-0950-9828
Article

The Relationship Between β-cell Function Indices and Sudomotor Function in Chinese Patients with Type 2 Diabetes

Bai-lu Cao
1   Department of Endocrinology, the affiliated Jinling Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
,
Yue Yao
2   Department of Endocrinology, Jinling Hospital, Nanjing University, Nanjing, Jiangsu, China
,
Yi-xin Xu
1   Department of Endocrinology, the affiliated Jinling Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
,
Jiang Fang
3   Department of Neurosurgery, Jinling Hospital, Southeast University, Nanjing, Jiangsu, China
,
Wen-jing Song
4   Department of Endocrinology, Jinling Hospital, Southern Medical University, Nanjing, Jiangsu, China
,
Bin Hu
2   Department of Endocrinology, Jinling Hospital, Nanjing University, Nanjing, Jiangsu, China
,
Qing-yu Guo
2   Department of Endocrinology, Jinling Hospital, Nanjing University, Nanjing, Jiangsu, China
,
Bin Lu
1   Department of Endocrinology, the affiliated Jinling Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
,
Jie Li
1   Department of Endocrinology, the affiliated Jinling Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
,
Ping Gu
1   Department of Endocrinology, the affiliated Jinling Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
,
Jia-qing Shao
1   Department of Endocrinology, the affiliated Jinling Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
› Author Affiliations
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Abstract

Purpose SUDOSCAN, a new non-invasive, quick, sensitive and quantitative technique, has been developed to detect diabetic peripheral neuropathy, and the latter is believed to be correlated with impaired β-cell function. The purpose of the present study was to investigate the associations between β-cell function indices and sudomotor function in Chinese type 2 diabetes.

Methods A total of 266 Chinese patients with type 2 diabetes were enrolled. Sudomotor function was assessed using electrochemical skin conductance of hands and feet. Pancreatic β-cell function was determined by homeostasis model assessment of β-cell function index, early-phase β-cell function indices and total β-cell function indices. Pearson correlation analysis and multiple linear stepwise regression analysis were carried out to explore the associations between β-cell function indices and sudomotor function.

Results Patients with lower early-phase β-cell function had lower electrochemical skin conductance levels of hands and feet and higher asymmetry ratio of hands and feet. Both Pearson correlation analysis and multiple linear stepwise regression analysis showed significantly positive relationships between early-phase β-cell function and electrochemical skin conductance levels of hands and feet, after controlling for potential confounders (P<0.05).

Conclusions Impaired early-phase β-cell function was positively associated with sudomotor dysfunction in Chinese patients with type 2 diabetes. We speculated that impaired early-phase β-cell function may be associated with the incidence of sudomotor dysfunction in patients with T2DM.



Publication History

Received: 07 October 2018
Received: 28 May 2019

Accepted: 04 June 2019

Article published online:
03 July 2019

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