Heilpflanzen aus der arabischen Tradition für die Wundbehandlung und Dermatologie

Zusammenfassung

Einige Pflanzen zur Wundbehandlung, die der mittelalterlichen arabischen Tradition entstammen, wurden in Europa bis weit in die Frühe Neuzeit hinein zu diesem Zweck genutzt, sind jedoch heute nahezu vergessen. Sie und ähnliche traditionelle Wundheilpflanzen bieten großes Potenzial nicht nur für die aktuelle Dermotherapie und Wundbehandlung, sondern auch für die zukünftige Suche nach Wirkstoffen.

Abstract

Medicinal plants of the Arabic tradition in wound treatment and dermatology

Some plants for wound treatment which derive from the medieval Arabic tradition were used in Europe well into early modern times, but are almost forgotten today. These particular plants and similar traditional wound healing plants offer great potential not only for current dermatology and wound treatment, but also for the future search for active ingredients.

• Literatur

• 1 Jäger S, Zahn T. Das neue Wund-Arzneimittel Episalvan®: Galenik und Studiendesign. Pharmakon 2016; 4: 349-355
• 2 Anagnostou S. Die Geschichte der Heilpflanzen als Basis neuer Forschungskonzepte. Pharmakon 2016; 4: 302-309
• 3 Friedrich C. Hohe Auszeichnung für Prof. Dr. Sabine Anagnostou. Dtsch Apoth Ztg 2017; 157: 2628
• 4 Müller J. Pflanzen zur Wundbehandlung der mittelalterlichen arabischen Heilkunde in der europäischen Tradition. Stuttgart: WVG; 2013
• 5 Hensel A, Spiegler V. Ein alternativer Weg zu neuen Wirkstoffen. Aktuelle ethnopharmakologische Forschung in Westafrika. Dtsch Apoth Ztg 2018; 158: 1604-1608
• 6 Shalini A, Prakash T, Rajput R. Effect of Punica granatum peel aqueous extract on normal and dexamethasone suppressed wound healing in wistar rats. Int J Pharm Sci Rev Res 2010; 5: 34-37
• 7 Pirbalouti AG, Koopayeh A, Karimi I. The wound healing activity of flower extracts of Punica granatum and Achillea kellalensis in wistar rats. Acta Pol Pharm 2010; 67: 107-110
• 8 Hayouni EA, Miled K, Boubaker S. et al. Hydroalcoholic extract based-ointment from Punica granatum L. peels with enhanced in vivo healing potential on dermal wounds. Phytomedicine 2011; 18: 976-984
• 9 Gould SW, Fielder MD, Kelly AF. et al. Antimicrobial pomegranate rind extracts – enhancement by Cu(II) and vitamin C combinations against clinical isolates of Pseudomonas aeruginosa . Br J Biomed Sci 2009; 66: 129-132
• 10 Nayak SB, Rodrigues V, Maharaj S, Bhogadi VS. Wound healing activity of the fruit skin of Punica granatum . J Med Food 2013; 16: 857-861
• 11 Nasiri E, Hosseinimehr SJ, Akbari J. et al. The effects of Punica granatum flower extract on skin injuries induced by burn in rats. Adv Pharmacol Sci 2017; 10: 1-8
• 12 Hadisi Z, Nourmohammadi J, Nassiri SM. The antibacterial and anti-inflammatory investigation of Lawsonia Inermis-gelatin-starch nano-fibrous dressing in burn wound. Int J Biol Macromol 2018; 107 (Part B): 2008-2019
• 13 Aqil F, Khan MS, Owais M, Ahmad I. Effect of certain bioactive plant extracts on clinical isolates of beta-lactamase producing methicillin resistant Staphylococcus aureus . J Basic Microbiol 2005; 45: 106-114
• 14 Muhammad HS, Muhammad S. The use of Lawsonia inermis Linn. (henna) in the management of burn wound infections. Afr J Biotechnol 2005; 4: 934-937
• 15 Nayak BS, Isitor G, Davis EM, Pillai GK. The evidence based wound healing activity of Lawsonia inermis Linn. Phytother Res 2007; 21: 827-831
• 16 European Medicines Agency (EMA), Committee on Herbal Medicinal Products (HMPC). : Pflanzliche Arzneimittel – Zusammenfassung für die Öffentlichkeit. Schachtelhalmkraut, Equisetum arvense L., herba. London: European Medicines Agency; , 5.. April 2016. , letzter Zugriff am 22. Februar 2019. http://www.ema.europa.eu/docs/de_DE/document_library/Herbal_-_Summary_of_assessment_report_for_the_public/2016/04/WC500205464.pdf
• 17 European Medicines Agency (EMA), Committee on Herbal Medicinal Products (HMPC):. Community herbal monograph on Commiphora molmol Engler, gummi-resina. London: European Medicines Agency; , 12.. Juli 2011. , letzter Zugriff am 22. Februar 2019. http://www.ema.europa.eu/docs/en_GB/document_library/Herbal_-_Community_herbal_monograph/2011/12/WC500119974.pdf
• 18 Elzayat EM, Auda SH, Alanazi FK, Al-Agamy MH. Evaluation of wound healing activity of henna, pomegranate and myrrh herbal ointment blend. Saudi Pharm J 2018; 26: 733-738
• 19 Alipour G, Dashti S, Hosseinzadeh H. Review of pharmacological effects of Myrtus communis L. and its active constituents. Phytother Res 2014; 28: 1125-1136
• 20 Müller J, Anagnostou S. Myrte(Myrtus communis L.) – ein Dermotherapeutikum aus dem verlorenen Paradies. Geschichte der Pharmazie 2013; 65: 1-9
• 21 Friedrich-Schiller-Universität Jena. , Institut für Pharmazie: Molekulare und zelluläre Funktionsweisen von Naturstoffen und Entwicklung als anti-inflammatorische und anti-neoplastische Arzneistoffe. Jena, Friedrich-Schiller-Universität [2018], letzter Zugriff am 9. August 2018 http://www.pharmazie.uni-jena.de/Abteilungen/Pharmazeutische_Medizinische+Chemie/Prof_+Dr_+Oliver +Werz/Forschungsgebiet_2.html
• 22 Wiechmann K, Müller H, König S. et al. Mitochondrial chaperonin HSP60 is the apoptosis-related target for Myrtucommulone. Cell Chem Biol 2017; 24: 614-623
• 23 Eid AM, Elmarzugi NA, Ayyash LM. et al. A Review on the cosmeceutical and external applications of Nigella sativa . J Trop Med 2017; 8: 1-6
• 24 Kalus U, Pruss A, Bystron J. et al. Effect of Nigella sativa (black seed) on subjective feeling in patients with allergic diseases. Phytother Res 2003; 17: 1209-1214
• 25 Hanafy MS, Hatem ME. Studies on the antimicrobial activity of Nigella sativa seed (black cumin). J Ethnopharmacol 1991; 34: 275-278
• 26 Al-Ghamdi MS. The anti-inflammatory, analgesic and antipyretic activity of Nigella sativa . J Ethnopharmacol 2001; 76: 45-48
• 27 Ahmed JH, Ibraheem AY, Al-Hamdi KI. Evaluation of efficacy, safety and antioxidant effect of Nigella sativa in patients with psoriasis: a randomized clinical trial. J Clin Exp Invest 2014; 5: 186-193
• 28 Yaman I, Durmus AS, Ceribasi S, Yaman M. Effects of Nigella sativa and silver sulfadiazine on burn wound healing in rats. Vet Med 2010; 55: 619-624
• 29 Selçuk CT, Durgun M, Tekin R. et al. Evaluation of the effect of thymoquinone treatment on wound healing in a rat burn model. J Burn Care Res 2013; 34: 274-281
• 30 Iskender B, Izgi K, Canatan H. Novel anti-cancer agent myrtucommulone-A and thymoquinone abrogate epithelial-mesenchymal transition in cancer cells mainly through the inhibition of PI3K / AKT signalling axis. Mol Cell Biochem 2016; 416: 71-84