Kardioprotektion durch Ernährung und Nährstoffe

Zusammenfassung

Ernährung bzw. Nährstoffe haben ein großes Potenzial für die Prävention und Therapie von Herz-Kreislauf-Erkrankungen. Wie Studien zeigen, gilt dieser Zusammenhang sowohl für verschiedene Ernährungsformen und einzelne Lebensmittelgruppen wie Nüsse, Olivenöl und Fisch als auch für einzelne Nährstoffe, beispielsweise ω-3-Fettsäuren, Magnesium und Vitamin D.

Schlüsselwörter

Kardiovaskuläre Erkrankung - oxidativer Stress - Mittelmeerkost - DASH-Diät - vegetarische Ernährung - Kohlenhydrate - Fett - Protein - Ballaststoffe - Früchte - Gemüse - Nüsse - Olivenöl - Fisch - Fleisch - gesüßte Getränke - Vollkorn - Alkohol - Kochsalz - Kalium - ω-3-Fettsäuren - Lycopin - Polyphenole - Magnesium - Vitamin D - Coenzym Q10

• Literatur

• 1 Benjamin EJ, Blaha MJ, Chiuve SE, Cushman M, Das SR, Deo R, de Ferranti SD, Floyd J, Fornage M, Gillespie C. et al. Heart Disease and Stroke Statistics-2017 Update: A Report from the American Heart Association. Circulation. 2017; 35 : e146-e603
• 2 Lacroix S, Cantin J, Nigam A. Contemporary issues regarding nutrition in cardiovascular rehabilitation. Ann Phys Rehabil Med 2017; 60 : 36-42
• 3 Mozaffarian D, Ludwig DS. Dietary guidelines in the 21st century: A time for food. JAMA 2010; 304 : 681-682
• 4 Griendling KK, FitzGerald GA. Oxidative stress and cardiovascular injury part 1: Basic mechanisms and in vivo monitoring of ROS. Circulation 2003; 108: 1912-1916
• 5 Ryoo S, Bhiunia A, Chang F, Shoukas A, Berkowitz DE, Romer LH. Ox-LDL-dependent activation of arginase II is dependent on the LOX-1 receptor and downstream RhoA signalling. Atherosclerosis 2011; 214 : 279-287
• 6 Casas R, Urpi-Sardà M, Sacanella E, Arranz S, Corella D, Castañer O, Lamuela-Raventós RM, Salas-Salvadó J, Lapetra J, Portillo MP. et al. Anti-Inflammatory Effects of the Mediterranean Diet in the Early and Late Stages of Atheroma Plaque Development. Mediat Inflamm 2017; 2017 : 3674390
• 7 Estruch R, Ros E, Salas-Salvadó J, Covas MI, Corella D, Arós F, Gómez-Gracia E, Ruiz-Gutiérrez V, Fiol M, Lapetra J. et al. Primary Prevention of Cardiovascular Disease with a Mediterranean Diet Supplemented with Extra-Virgin Olive Oil or Nuts. N Engl J Med 2018; 378 : e34
• 8 Estruch R, Martínez-González MA, Corella D, Salas-Salvadó J, Ruiz-Gutiérrez V, Covas MI, Fiol M, Gómez-Gracia E, López-Sabater MC, Vinyoles E. et al. Effects of a Mediterranean style diet on cardiovascular risk factors: A randomized trial. Ann Intern Med 2006; 145 : 1-11
• 9 Tektonidis T, Åkesson A, Gigante B, Wolk A, Larsson SC. A Mediterranean diet and risk of myocardial infarction, heart failure and stroke: A population-based cohort study. Atherosclerosis 2015; 243 : 93-98
• 10 Covas MI, de la Torre R, Fito M. Virgin olive oil: A key food for cardiovascular risk protection. Br J Nutr 2015; 113 (Suppl. 2): S19-S28
• 11 Bansilal S, Farkouh ME, Fuster V. Role of insulin resistance and hyperglycemia in the development of atherosclerosis. Am J Cardiol 2007; 99 : 6B-14B
• 12 Dehghan M, Mente A, Zhang X, Swaminathan S, Li W, Mohan V, Iqbal R, Kumar R, Wentzel-Viljoen E, Rosengren A. et al. Associations of fats and carbohydrate intake with cardiovascular disease and mortality in 18 countries from five continents (PURE): A prospective cohort study. Lancet 2017; 390 : 2050-2062
• 13 Mente A, Dehghan M, Rangarajan S, McQueen M, Dagenais G, Wielgosz A, Lear S, Li W, Chen H, Yi S. et al. Association of dietary nutrients with blood lipids and blood pressure in 18 countries: A cross-sectional analysis from the PURE study. Lancet Diabetes Endocrinol 2017; 10 : 774-787
• 14 Li Y, Hruby A, Bernstein AM, Ley SH, Wang DD, Chiuve SE, Sampson L, Rexrode KM, Rimm EB, Willett WC. et al. Saturated Fat as Compared with Unsaturated Fats and Sources of Carbohydrates in Relation to Risk of Coronary Heart Disease: A Prospective Cohort Study. J Am Coll Cardiol 2015; 66 : 1538-1548
• 15 Skeaff CM, Miller J. Dietary fat and coronary heart disease: summary of evidence from prospective cohort and randomised controlled trials. Ann Nutr Metab 2009; 55 : 173-201
• 16 Siri-Tarino PW, Sun Q, Hu FB, Krauss RM. Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease. Am J Clin Nutr 2010; 91 : 502-509
• 17 Jakobsen MU, O’Reilly EJ, Heitmann BL, Pereira MA, Balter K, Fraser GE, Goldbourt U, Hallmans G, Knekt P, Liu S, Pietinen P, Spiegelman D, Stevens J, Virtamo J, Willett WC, Ascherio A. Major types of dietary fat and risk of coronary heart disease: a pooled analysis of 11 cohort studies. Am J Clin Nutr 2009; 89 : 1425-1432
• 18 Müllner E, Plasser E, Brath H, Waldschütz W, Forster E, Kundi M, Wagner K-H. Impact of polyunsaturated vegetable oils on adiponectin levels, glycaemia and blood lipids in individuals with type 2 diabetes: A randomised, double-blind intervention study. J Hum Nutr Diet 2014; 27 : 468-478
• 19 Fernandez ML, West KL. Mechanisms by which dietary fatty acids modulate plasma lipids. J Nutr 2005; 135 : 2075-2078
• 20 Benes LB, Bassi NS, Davidson MH. Omega-3 carboxylic acids monotherapy and combination with statins in the management of dyslipidemia. Vasc Health Risk Manag 2016; 12 : 481-490
• 21 Singh S, Arora RR, Singh M, Khosla S. Eicosapentaenoic acid versus docosahexaenoic acid as options for vascular risk prevention. Am J Ther 2016; 23 : e905-e910
• 22 Stamler J, Elliott P, Kesteloot H, Nichols R, Claeys G, Dyer AR, Stamler R. Inverse relation of dietary protein markers with blood pressure. Findings for 10,020 men and women in the INTERSALT Study. INTERSALT Cooperative Research Group. INTERnational study of SALT and blood pressure. Circulation 1996; 94 : 1629-1634
• 23 He J, Wofford MR, Reynolds K, Chen J, Chen CS, Myers L, Minor DL, Elmer PJ, Jones DW, Whelton PK. Effect of dietary protein supplementation on blood pressure: a randomized, controlled trial. Circulation 2011; 124 : 589-595
• 24 North CJ, Venter CS, Jerling JC. The effects of dietary fibre on C-reactive protein, an inflammation marker predicting cardiovascular disease. Eur J Clin Nutr 2009; 63: 921-933
• 25 Wood AD, Strachan AA, Thies F, Aucott LS, Reid DM, Hardcastle AC, Mavroeidi A, Simpson WG, Duthie GG, Macdonald HM. Patterns of dietary intake and serum carotenoid and tocopherol status are associated with biomarkers of chronic low-grade systemic inflammation and cardiovascular risk. Br J Nutr 2014; 112: 1341-1352
• 26 Piccand E, Vollenweider P, Guessous I, Marques-Vidal P. Association between dietary intake and inflammatory markers: Results from the CoLaus study. Public Health Nutr 2018; 18: 1-8
• 27 Guasch-Ferré M, Liu X, Malik VS, Sun Q, Willett WC, Manson JE, Rexrode KM, Li Y, Hu FB, Bhupathiraju SN. Nut Consumption and Risk of Cardiovascular Disease. J Am Coll Cardiol 2017; 70: 2519-2532
• 28 Aune D, Keum N, Giovannucci E, Fadnes LT, Boffetta P, Greenwood DC, Tonstad S, Vatten LJ, Riboli E, Norat T. Nut consumption and risk of cardiovascular disease, total cancer, all-cause and cause-specific mortality: A systematic review and dose-response meta-analysis of prospective studies. BMC Med 2016; 14 : 207
• 29 Oliveras-Lópeza MJ, Bernáab G, Jurado-Ruizab E, de la Serrana LG, Martínab F. Consumption of extra-virgin olive oil rich in phenolic compounds has beneficial antioxidant effects in healthy human adults. J Funct Foods 2014; 10: 475-484
• 30 Mozaffarian D, Rimm EB. Fish intake, contaminants, and human health: evaluating the risks and the benefits. JAMA 2006; 296 : 1885-1899
• 31 Wang C, Harris WS, Chung M, Lichtenstein AH, Balk EM, Kupelnick B, Jordan HS, Lau J. n-3 Fatty acids from fish or fish-oil supplements, but not [H9251]-linolenic acid, benefit cardiovascular disease outcomes in primary- and secondary-prevention studies: a systematic review. Am J Clin Nutr 2006; 84: 5-17
• 32 Mozaffarian D, Gottdiener JS, Siscovick DS. Intake of tuna or other broiled or baked fish versus fried fish and cardiac structure, function, and hemodynamics. Am J Cardiol 2006; 97 : 216-222
• 33 Mente A, de Koning L, Shannon HS, Anand SS. A systematic review of the evidence supporting a causal link between dietary factors and coronary heart disease. Arch Intern Med 2009; 169 : 659-669
• 34 Micha R, Wallace S, Mozaffarian D. Red and processed meat consumption and risk of incident coronary heart disease, stroke, and diabetes: a systematic review and meta-analysis. Circulation 2010; 121 : 2271-2283
• 35 Estruch R, Sacanella E, Badia E, Antúnez E, Nicolás JM, Fernández-Solá J, Rotilio D, de Gaetano G, Rubin E, Urbano-Márquez A. Different effects of red wine and gin consumption on inflammatory biomarkers of atherosclerosis: A prospective randomized crossover trial. Effects of wine on inflammatory markers. Atherosclerosis 2004; 175:: 117-123
• 36 De Gaetano G, Constanzo S, Castelnuovo AD, Badimon L, Bejko D, Alkerwi A, Chiva-Blanch G, Estruch R, La Vecchia C, Panico S. Effects of moderate beer consumption on health and disease: A consensus document. Nutr Metab Cardiovasc Dis 2016; 26 : 443-467
• 37 Wannamethee SG, Shaper AG. Type of alcoholic drink and risk of major coronary heart disease event and all-cause mortality. Am J Public Health 1999; 89 : 685-690
• 38 He J, Gu D, Kelly TN, Hixson JE, Rao DC, Jaquish CE, Chen J, Zhao Q, Gu C, Huang J, Shimmin LC, Chen JC, Mu J, Ji X, Liu DP, Whelton PK. Genetic variants in the renin-angiotensin-aldosterone system and blood pressure responses to potassium intake. J Hypertens 2011; 29 : 1719-1730
• 39 Cheng HM, Koutsidis G, Lodge JK, Ashor A, Siervo M, Lara J. Tomato and lycopene supplementation and cardiovascular risk factors: A systematic review and meta-analysis. Atherosclerosis 2017; 257 : 100-108
• 40 González-Gallego J, García-Mediavilla MV, Sánchez-Campos S, Tuñón MJ. Fruit polyphenols immunity and inflammation. Br J Nutr 2010; ; 104:: S15-S27
• 41 Bahramsoltani R, Ebrahimi F, Farzaei MH, Baratpourmoghaddam A, Ahmadi P, Rostamiasrabadi P, Rasouli Amirabadi AH, Rahimi R. Dietary polyphenols for atherosclerosis: A comprehensive review and future perspectives. Crit Rev Food Sci Nutr 2019; 59 : 114-132 ; doi 10.1080 / 10408398.2017.1360244
• 42 Medina-Remón A, Casas R, Tressserra-Rimbau A, Ros E, Martínez-González MA, Fitó M, Corella D, Salas-Salvadó J, Lamuela-Raventos RM, Estruch R. et al. Polyphenol intake from a Mediterranean diet decreases inflammatory biomarkers related to atherosclerosis: A substudy of the PREDIMED trial. Br J Clin Pharmacol 2017; 83:: 114-128
• 43 Schwingshackl L, Hoffmann G. Monounsaturated fatty acids, olive oil and health status: A systematic review and meta-analysis of cohort studies. Lipids Health Dis 2014; 13 : 154
• 44 Rodriguez AJ, Mousa A, Ebeling PR, Scott D, de Courten B. Effects of vitamin D supplementation on inflammatory markers in heart failure: A systematic review and meta-analysis of randomized controlled trials. Sci Rep 2018; 8 : 1169
• 45 Wang Q, Zhu Z, Liu Y, Tu X, He J. Relationship between serum vitamin D levels and inflammatory markers in acute stroke patients. Brain Behav 2018; 8 : e00885