Primär- und Sekundärprävention des Multiplen Myeloms

Abstract

Lifestyle factors such as diet, physical activity and exposure to noxious agents are modifiable factors that have a significant impact on the state of health and life expectancy of humans. The following article is intended to provide an overview of current knowledge on the influence of these lifestyle factors on the development and progression of multiple myeloma and is dedicated to the question of the extent to which prevention strategies can be usefully applied.

Verschiedene Lebensstilfaktoren können die Entwicklung und den Progress eines Multiplen Myeloms (MM) beeinflussen. Dieser Beitrag präsentiert einen kurzen Überblick über die wichtigsten vermeidbaren Risikofaktoren und stellt Strategien zur Prävention MM-assoziierter Symptome und therapiebedingter Nebenwirkungen vor. Dabei liegt der Schwerpunkt auf den Empfehlungen für den Bereich der Ernährungs- und der Bewegungstherapie.

Schlüsselwörter

Multiples Myelom - Adipositas - Ernährungstherapie - Bewegungstherapie

Key words

multiple myeloma - obesity - nutritional therapy - exercise therapy

• Literatur

• 1 Schienkiewitz A, Mensink GBM, Kuhnert R. et al Übergewicht und Adipositas bei Erwachsenen in Deutschland. J Health Monitoring 2017; 2: 21-28 . doi:10.17886/RKI-GBE-2017-025
• 2 Lauby-Secretan B, Scoccianti C, Loomis D. et al Body Fatness and Cancer--Viewpoint of the IARC Working Group. N Engl J Med 2016; 375: 794-798 . doi:10.1056/NEJMsr1606602
• 3 Rajkumar SV. Multiple myeloma: 2016 update on diagnosis, risk-stratification, and management. Am J Hematol 2016; 91: 719-734 . doi:10.1002/ajh.24402
• 4 Turesson I, Bjorkholm M, Blimark CH. et al. Rapidly changing myeloma epidemiology in the general population: Increased incidence, older patients, and longer survival. Eur J Haematol 2018;
• 5 Bourke L, Rosario D, Copeland R. et al Physical activity for cancer survivors. BMJ 2012; 344: d7998 . doi:10.1136/bmj.d7998
• 6 Stone P, Richardson A, Ream E. et al Cancer-related fatigue: Inevitable, unimportant and untreatable? Results of a multi-centre patient survey. Ann Oncol 2000; 11: 971-976 . doi:10.1023/A:1008318932641
• 7 Morrow GR, Andrews PLR, Hickok JT. et al Fatigue associated with cancer and its treatment. Support Care Cancer 2002; 10: 389-398 . doi:10.1007/s005200100293
• 8 Psaltopoulou T, Sergentanis TN, Kanellias N. et al Tobacco smoking and risk of multiple myeloma: a meta-analysis of 40 observational studies. Int J Cancer 2013; 132: 2413-2431 . doi:10.1002/ijc.27898
• 9 Psaltopoulou T, Sergentanis TN, Sergentanis IN. et al Alcohol intake, alcoholic beverage type and multiple myeloma risk: a meta-analysis of 26 observational studies. Leuk Lymphoma 2015; 56: 1484-1501 . doi:10.3109/10428194.2014.956312
• 10 Ugai T, Ito H, Oze I. et al Association of BMI, Smoking, and Alcohol with Multiple Myeloma Mortality in Asians: A Pooled Analysis of More than 800–000 Participants in the Asia Cohort Consortium. Cancer Epidemiol Biomarkers Prev 2019; 28: 1861-1867 . doi:10.1158/1055-9965.EPI-19-0389
• 11 Chang SH, Luo S, Thomas TS. et al Obesity and the Transformation of Monoclonal Gammopathy of Undetermined Significance to Multiple Myeloma: A Population-Based Cohort Study. J Natl Cancer Inst 2017; 109: djw264 . doi:10.1093/jnci/djw264
• 12 Allegra A, Innao V, Gerace D. et al The adipose organ and multiple myeloma: Impact of adipokines on tumor growth and potential sites for therapeutic intervention. Eur J Intern Med 2018; 53: 12-20 . doi:10.1016/j.ejim.2018.05.033
• 13 Conroy MJ, Dunne MR, Donohoe CL. et al Obesity-associated cancer: an immunological perspective. Proc Nutr Soc 2016; 75: 125-138 . doi:10.1017/S0029665115004176
• 14 Bullwinkle EM, Parker MD, Bonan NF. et al Adipocytes contribute to the growth and progression of multiple myeloma: Unraveling obesity related differences in adipocyte signaling. Cancer Lett 2016; 380: 114-121 . doi:10.1016/j.canlet.2016.06.010
• 15 Morris EV, Edwards CM. Bone marrow adiposity and multiple myeloma. Bone 2019; 118: 42-46 . doi:10.1016/j.bone.2018.03.011
• 16 Jochem C, Leitzmann MF, Keimling M. et al Physical activity in relation to risk of hematologic cancers: a systematic review and meta-analysis. Cancer Epidemiol Biomarkers Prev 2014; 23: 833-846 . doi:10.1158/1055-9965.EPI-13-0699
• 17 Jones LW, Courneya KS, Vallance JKH. et al Association between exercise and quality of life in multiple myeloma cancer survivors. Support Care Cancer 2004; 12: 780-788 . doi:10.1007/s00520-004-0668-4
• 18 Khuder SA, Mutgi AB. Meta-analyses of multiple myeloma and farming. Am J Ind Med 1997; 32: 510-516 . doi:10.1002/(sici)1097-0274(199711)32:5<510::aid-ajim11>3.0.co;2-5
• 19 Brandt-Rauf PW, Fallon LF, Tarantini T. et al Health hazards of fire fighters: exposure assessment. Br J Ind Med 1988; 45: 606-612 . doi:10.1136/oem.45.9.606
• 20 Takkouche B, Regueira-Méndez C, Montes-Martínez A. Risk of cancer among hairdressers and related workers: a meta-analysis. Int J Epidemiol 2009; 38: 1512-1531 . doi:10.1093/ije/dyp283
• 21 Te Morenga L, Mallard S, Mann J. Dietary sugars and body weight: systematic review and meta-analyses of randomised controlled trials and cohort studies. BMJ 2012; 346: e7492 . doi:10.1136/bmj.e7492
• 22 Whiteman DC, Wilson LF. The fractions of cancer attributable to modifiable factors: A global review. Cancer Epidemiol 2016; 44: 203-221 . doi:10.1016/j.canep.2016.06.013
• 23 Wang X, Ouyang Y, Liu J. et al Fruit and vegetable consumption and mortality from all causes, cardiovascular disease, and cancer: systematic review and dose-response meta-analysis of prospective cohort studies. BMJ 2014; 349: g5472 . doi:10.1136/bmj.g5472
• 24 Thordardottir M, Lindqvist EK, Lund SH. et al Dietary intake is associated with risk of multiple myeloma and its precursor disease. PLoS ONE 2018; 13: e0206047 . doi:10.1371/journal.pone.0206047
• 25 Lee DH, Fung TT, Tabung FK. et al Dietary Pattern and Risk of Multiple Myeloma in Two Large Prospective US Cohort Studies. JNCI Cancer Spectr 2019; 3: pkz025 . doi:10.1093/jncics/pkz025
• 26 Gan JH, Sim CYL, Santorelli LA. The effectiveness of exercise programmes in patients with multiple myeloma: A literature review. Crit Rev Oncol Hematol 2016; 98: 275-289 . doi:10.1016/j.critrevonc.2015.11.005
• 27 Patel AV, Friedenreich CM, Moore SC. et al American College of Sports Medicine Roundtable Report on Physical Activity, Sedentary Behavior, and Cancer Prevention and Control. Med Sci Sports Exerc 2019; 51: 2391-2402 . doi:10.1249/MSS.0000000000002117
• 28 Knips L, Bergenthal N, Streckmann F. et al Aerobic physical exercise for adult patients with haematological malignancies. Cochrane Database Syst Rev 2019; 1: CD009075 . doi:10.1002/14651858.CD009075.pub3
• 29 Campbell KL, Winters-Stone KM, Wiskemann J. et al Exercise Guidelines for Cancer Survivors. Med Sci Sports Exerc 2019; 51: 2375-2390 . doi:10.1249/MSS.0000000000002116
• 30 Keilani M, Kainberger F, Pataraia A. et al Typical aspects in the rehabilitation of cancer patients suffering from metastatic bone disease or multiple myeloma. Wien Klin Wochenschr 2019; 131: 567-575 . doi:10.1007/s00508-019-1524-3
• 31 Larsen RF, Jarden M, Minet LR. et al Supervised and home-based physical exercise in patients newly diagnosed with multiple myeloma – a randomized controlled feasibility study. Pilot Feasibility Stud 2019; 5: 185 . doi:10.1186/s40814-019-0518-2
• 32 Crevenna R, Kainberger F, Wiltschke C. et al Cancer rehabilitation: current trends and practices within an Austrian University Hospital Center. Disabil Rehabil 2020; 42: 2-7 . doi:10.1080/09638288.2018.1514665
• 33 Duregon F, Vendramin B, Bullo V. et al Effects of exercise on cancer patients suffering chemotherapy-induced peripheral neuropathy undergoing treatment: A systematic review. Crit Rev Oncol Hematol 2018; 121: 90-100 . doi:10.1016/j.critrevonc.2017.11.002
• 34 Cenik F, Keilani M, Hasenöhrl T. et al Relevant parameters for recommendations of physical activity in patients suffering from multiple myeloma. Wien Klin Wochenschr 2019; 98: 951 . doi:10.1007/s00508-019-01582-z
• 35 Schönsteiner SS, Bauder Mißbach H, Benner A. et al A randomized exploratory phase 2 study in patients with chemotherapy-related peripheral neuropathy evaluating whole-body vibration training as adjunct to an integrated program including massage, passive mobilization and physical exercises. Exp Hematol Oncol 2017; 6: 5 . doi:10.1186/s40164-017-0065-6
• 36 Dalla Via J, Daly RM, Fraser SF. The effect of exercise on bone mineral density in adult cancer survivors: a systematic review and meta-analysis. Osteoporos Int 2018; 29: 287-303 . doi:10.1007/s00198-017-4237-3