Neurologie up2date, Table of Contents Neurologie up2date 2020; 3(04): 387-405DOI: 10.1055/a-1011-7225 Kopfschmerz und andere Schmerzsyndrome Neuropathische Schmerzen Luisa Kreß , Nurcan Üçeyler Recommend Article Abstract Buy Article All articles of this category Neuropathische Schmerzen begegnen ÄrztInnen aufgrund ihrer vielfältigen Ätiologie und als mögliche Begleiterscheinung unterschiedlicher Krankheitsbilder in nahezu allen Fachbereichen. Zur adäquaten Therapie und Symptomkontrolle ist es wichtig, neuropathische Schmerzen als eigene Schmerzform zu differenzieren. Eine zielgerichtete Anamnese, die ausführliche klinische Untersuchung und ggf. eine erweiterte apparative Diagnostik ermöglichen die Abgrenzung neuropathischer Schmerzen von nozizeptiven und noziplastischen Schmerzen. Full Text References Literatur 1 Nijs J, Apeldoorn A, Hallegraeff H. et al. Low back pain: guidelines for the clinical classification of predominant neuropathic, nociceptive, or central sensitization pain. Pain Physician 2015; 18: E333-346 2 Aydede M, Shriver A. Recently introduced definition of "nociplastic pain" by the International Association for the Study of Pain needs better formulation. Pain 2018; 159: 1176-1177 3 Finnerup NB, Haroutounian S, Kamerman P. et al. Neuropathic pain: an updated grading system for research and clinical practice. Pain 2016; 157: 1599-1606 4 Schlereth T. et al. Deutsche Gesellschaft für Neurologie, Hrsg.. Diagnose und nicht interventionelle Therapie neuropathischer Schmerzen, Sk2-Leitlinie. Leitlinien für Diagnostik und Therapie in der Neurologie 2019. Im Internet: (Stand: 24.09.2020) https://www.awmf.org/leitlinien/detail/ll/030–114.html 5 Watson JC, Sandroni P. Central neuropathic pain syndromes. Mayo Clin Proc 2016; 91: 372-385 6 Baron R, Binder A, Wasner G. Neuropathic pain: diagnosis, pathophysiological mechanisms, and treatment. Lancet Neurol 2010; 9: 807-819 7 Hung AL, Lim M, Doshi TL. Targeting cytokines for treatment of neuropathic pain. Scand J Pain 2017; 17: 287-293 8 Bennett DL, Clark AJ, Huang J. et al. The role of voltage-gated sodium channels in pain signaling. Physiol Rev 2019; 99: 1079-1151 9 Roa-Coria JE, Pineda-Farias JB, Barragán-Iglesias P. et al. Possible involvement of peripheral TRP channels in the hydrogen sulfide-induced hyperalgesia in diabetic rats. BMC Neurosci 2019; 20: 1 10 Rolke R, Magerl W, Campbell KA. et al. Quantitative sensory testing: a comprehensive protocol for clinical trials. Eur J Pain 2006; 10: 77-88 11 Hoeijmakers JG, Faber CG, Lauria G. et al. Small-fibre neuropathies--advances in diagnosis, pathophysiology and management. Nat Rev Neurol 2012; 8: 369-379 12 Serra J, Campero M, Ochoa J. et al. Activity-dependent slowing of conduction differentiates functional subtypes of C fibres innervating human skin. J Physiol 1999; 515 : 799-811 13 Tavakoli M, Malik RA. Corneal confocal microscopy: a novel non-invasive technique to quantify small fibre pathology in peripheral neuropathies. J Vis Exp 2011; 14 Thaisetthawatkul P, Fernandes Filho JA, Herrmann DN. Contribution of QSART to the diagnosis of small fiber neuropathy. Muscle Nerve 2013; 48: 883-888 15 De Greef BTA, Hoeijmakers JGJ, Gorissen-Brouwers CML. et al. Associated conditions in small fiber neuropathy - a large cohort study and review of the literature. Eur J Neurol 2018; 25: 348-355 16 Tavee JO. Office approach to small fiber neuropathy. Cleve Clin J Med 2018; 85: 801-812 17 Deckert S, Kaiser U, Kopkow C. et al. A systematic review of the outcomes reported in multimodal pain therapy for chronic pain. Eur J Pain 2016; 20: 51-63 18 Finnerup NB, Attal N, Haroutounian S. et al. Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis. Lancet Neurol 2015; 14: 162-173 19 Binder A, Baron R. The Pharmacological Therapy of Chronic Neuropathic Pain. Dtsch Arztebl Int 2016; 113: 616-625 20 Derry S, Wiffen PJ, Kalso EA. et al. Topical analgesics for acute and chronic pain in adults - an overview of Cochrane Reviews. Cochrane Database Syst Rev 2017; 5: Cd008609
