Planta Medica, Inhaltsverzeichnis Planta Med 2020; 86(01): 19-25DOI: 10.1055/a-1028-7786 Biological and Pharmacological Activity Original Papers Georg Thieme Verlag KG Stuttgart · New York Antiplasmodial Bis-Indole Alkaloids from the Bark of Flindersia pimenteliana Luke P. Robertson 1 Environmental Futures Research Institute, Griffith University, Southport, Gold Coast, Australia 2 Griffith Institute for Drug Discovery, Griffith University, Nathan, Brisbane, Australia , Leonardo Lucantoni 2 Griffith Institute for Drug Discovery, Griffith University, Nathan, Brisbane, Australia , Vicky M. Avery 2 Griffith Institute for Drug Discovery, Griffith University, Nathan, Brisbane, Australia , Anthony R. Carroll 1 Environmental Futures Research Institute, Griffith University, Southport, Gold Coast, Australia 2 Griffith Institute for Drug Discovery, Griffith University, Nathan, Brisbane, Australia › Institutsangaben Artikel empfehlen Abstract Artikel einzeln kaufen Abstract Three new (1–3) and 2 known (4–5) bis-indole alkaloids were identified from the bark of Flindersia pimenteliana (Rutaceae). The structures of 1–3 were elucidated on the basis of their (+)-HRESESIMS and 2D NMR spectroscopic data. Antiplasmodial activity for 1–3 against chloroquine sensitive (3D7) and chloroquine-resistant (Dd2) Plasmodium falciparum is also reported, with IC50 values ranging from 0.96 to 2.41 µg/mL. These results expand our knowledge of the structure-activity relationships of potently antiplasmodial isoborreverine-type alkaloids, the bioactivity of which have recently attracted significant attention in the literature. 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