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Planta Med 2020; 86(01): 70-77
DOI: 10.1055/a-1031-7283
Natural Product Chemistry and Analytical Studies
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Barringtogenol C-type Triterpenoid Saponins from the Stem Bark of Norway Maple (Acer Platanoides)

Wen Xu‡
1   Institute of Microbial Pharmaceuticals, College of Life and Health Sciences, Northeastern University, Shenyang, P. R. China
,
Lu Zhang‡
2   Bioactive Botanical Research Laboratory, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI, USA
3   College of Life Science, Jiangxi Normal University, Nanchang, P. R. China
,
Raed Omar
2   Bioactive Botanical Research Laboratory, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI, USA
,
Wei Liu
1   Institute of Microbial Pharmaceuticals, College of Life and Health Sciences, Northeastern University, Shenyang, P. R. China
,
Zhengxi Wei
2   Bioactive Botanical Research Laboratory, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI, USA
,
Zengguang Zhang
1   Institute of Microbial Pharmaceuticals, College of Life and Health Sciences, Northeastern University, Shenyang, P. R. China
,
Yu Mu
1   Institute of Microbial Pharmaceuticals, College of Life and Health Sciences, Northeastern University, Shenyang, P. R. China
,
Navindra P. Seeram
2   Bioactive Botanical Research Laboratory, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI, USA
,
Xueshi Huang
1   Institute of Microbial Pharmaceuticals, College of Life and Health Sciences, Northeastern University, Shenyang, P. R. China
,
Hang Ma
2   Bioactive Botanical Research Laboratory, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI, USA
4   School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, P. R. China
,
Liya Li
1   Institute of Microbial Pharmaceuticals, College of Life and Health Sciences, Northeastern University, Shenyang, P. R. China
› Author Affiliations
Further Information

Publication History

received 07 August 2019
revised 10 October 2019

accepted 18 October 2019

Publication Date:
31 October 2019 (online)

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Abstract

Four new barringtogenol C-type triterpenoid saponins, namely acerplatanosides A – D (1–4), along with 22 known compounds (5–26), were isolated from the stem bark of Norway maple (Acer platanoides). Their structures were elucidated on the basis of comprehensive spectroscopic analyses and chemical hydrolysis. This is the first report of triterpenoid saponins isolated from Norway maple. Compounds 1, 3, and 4 showed cytotoxicity against 4 human cancer cell lines with IC50 values ranging from 9.4 to 39.5 µM.

Key words

Acer platanoides - Sapindaceae - Norway maple - Barringtogenol C-type - triterpenoid saponins - cytotoxicity

Supporting Information

    Detailed IR, MS, and NMR spectra of compounds 1–4, GC-MS chromatogram of monosaccharides derivatives, and the cell viability data of each compound in each cell line, the extraction and isolation of the known compounds 5–26 are available as Supporting Information.

  • Supporting Information
 

  • References

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