Barringtogenol C-type Triterpenoid Saponins from the Stem Bark of Norway Maple (Acer Platanoides)

Wen Xu; Lu Zhang; Raed Omar; Wei Liu; Zhengxi Wei; Zengguang Zhang; Yu Mu; Navindra P. Seeram; Xueshi Huang; Hang Ma; Liya Li

doi:10.1055/a-1031-7283

Planta Medica, Inhaltsverzeichnis

Planta Med 2020; 86(01): 70-77
DOI: 10.1055/a-1031-7283

Natural Product Chemistry and Analytical Studies

Original Papers

Georg Thieme Verlag KG Stuttgart · New York

Barringtogenol C-type Triterpenoid Saponins from the Stem Bark of Norway Maple (Acer Platanoides)

Wen Xu‡

¹Institute of Microbial Pharmaceuticals, College of Life and Health Sciences, Northeastern University, Shenyang, P. R. China

,

Lu Zhang‡

²Bioactive Botanical Research Laboratory, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI, USA

³College of Life Science, Jiangxi Normal University, Nanchang, P. R. China

,

Raed Omar

²Bioactive Botanical Research Laboratory, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI, USA

,

Wei Liu

¹Institute of Microbial Pharmaceuticals, College of Life and Health Sciences, Northeastern University, Shenyang, P. R. China

,

Zhengxi Wei

²Bioactive Botanical Research Laboratory, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI, USA

,

Zengguang Zhang

¹Institute of Microbial Pharmaceuticals, College of Life and Health Sciences, Northeastern University, Shenyang, P. R. China

,

Yu Mu

¹Institute of Microbial Pharmaceuticals, College of Life and Health Sciences, Northeastern University, Shenyang, P. R. China

,

Navindra P. Seeram

²Bioactive Botanical Research Laboratory, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI, USA

,

Xueshi Huang

¹Institute of Microbial Pharmaceuticals, College of Life and Health Sciences, Northeastern University, Shenyang, P. R. China

,

Hang Ma

²Bioactive Botanical Research Laboratory, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI, USA

⁴School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, P. R. China

,

Liya Li

¹Institute of Microbial Pharmaceuticals, College of Life and Health Sciences, Northeastern University, Shenyang, P. R. China

› Institutsangaben

Abstract

Four new barringtogenol C-type triterpenoid saponins, namely acerplatanosides A – D (1–4), along with 22 known compounds (5–26), were isolated from the stem bark of Norway maple (Acer platanoides). Their structures were elucidated on the basis of comprehensive spectroscopic analyses and chemical hydrolysis. This is the first report of triterpenoid saponins isolated from Norway maple. Compounds 1, 3, and 4 showed cytotoxicity against 4 human cancer cell lines with IC₅₀ values ranging from 9.4 to 39.5 µM.

Key words

Acer platanoides - Sapindaceae - Norway maple - Barringtogenol C-type - triterpenoid saponins - cytotoxicity

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Referenzen

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