An Unsuccessful Attempt to Confirm the Occurrence of 4′-O-β-d-Glucosyl-9-O-(6″-deoxysaccharosyl)olivil in Valerian Root

Jandirk Sendker; Matthias Lechtenberg; Andreas Hensel

doi:10.1055/a-1078-5195

Planta Medica, Table of Contents

Planta Med 2020; 86(15): 1133-1139
DOI: 10.1055/a-1078-5195

Natural Product Chemistry and Analytical Studies

Original Papers

An Unsuccessful Attempt to Confirm the Occurrence of 4′-O-β- d-Glucosyl-9-O-(6″-deoxysaccharosyl)olivil in Valerian Root^{[
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Jandirk Sendker

Institute of Pharmaceutical Biology and Phytochemistry, University of Münster, Münster, Germany

,

Matthias Lechtenberg

Institute of Pharmaceutical Biology and Phytochemistry, University of Münster, Münster, Germany

,

Andreas Hensel

Institute of Pharmaceutical Biology and Phytochemistry, University of Münster, Münster, Germany

› Author Affiliations

Abstract

The lignan 4′-O-β- d-glucosyl-9-O-(6″-deoxysaccharosyl)olivil had previously been discovered in a methanolic extract of valerian root (Valeriana officinalis agg.) and characterized as a potent partial agonist at the A₁ adenosine receptors. Today, countless scientific sources, webpages, and press articles mention this compound and discuss it as an active constituent for the sedative effect of this herbal drug. As no second report confirmed the occurrence of this lignan in valerian root during the 20 years since its first description in 1998, we intended to re-prove its presence by means of LCMS using other genuine or added lignans as a quantitative benchmark. Whilst those lignans were clearly detectable in methanolic valerian extracts of all six investigated batches of valerian root, no positive proof of 4′-O-β- d-glucosyl-9-O-(6″-deoxysaccharosyl)olivil was achieved. Our result suggests that this compound does not occur regularly in valerian root in the amounts expected from the single report on the occurrence of this compound.

Key words

Valeriana officinalis - Valeriana edulis - Caprifoliaceae - lignans - olivil - LCMS

Full Text

References

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Supplementary Material

Supporting Information

An Unsuccessful Attempt to Confirm the Occurrence of 4′-O-β- d-Glucosyl-9-O-(6″-deoxysaccharosyl)olivil in Valerian Root[ # ]

An Unsuccessful Attempt to Confirm the Occurrence of 4′-O-β- d-Glucosyl-9-O-(6″-deoxysaccharosyl)olivil in Valerian Root^{[
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