Age and Sex Influence Thyroid Hormone Effects in Target Tissues with
                    Organ-Specific Responses

Helena Kerp; Janina Gassen; Dagmar Führer

doi:10.1055/a-1083-6272

Experimental and Clinical Endocrinology & Diabetes, Table of Contents

Exp Clin Endocrinol Diabetes 2020; 128(06/07): 469-472
DOI: 10.1055/a-1083-6272

Mini-Review

Age and Sex Influence Thyroid Hormone Effects in Target Tissues with Organ-Specific Responses

Helena Kerp

¹Department of Endocrinology, Diabetes and Metabolism, University Hospital Essen, University of Duisburg-Essen, Essen, Germany

,

Janina Gassen

¹Department of Endocrinology, Diabetes and Metabolism, University Hospital Essen, University of Duisburg-Essen, Essen, Germany

,

Dagmar Führer

¹Department of Endocrinology, Diabetes and Metabolism, University Hospital Essen, University of Duisburg-Essen, Essen, Germany

› Author Affiliations

Abstract

Age and sex impact prevalence and clinical features of thyroid disease. Thyroid dysfunction occurs with a higher frequency in elderly patients and females. Moreover, age alters clinical presentation of hyper- and hypothyroidism and onset of thyroid hormone (TH) related co-morbidities leading to increased risk for underdiagnosis and maltreatment in the elderly. Rodent models allow further insights into mechanisms of age- and sex-dependent TH action in target tissues. In this review, we summarize findings from mouse studies showing distinct effects of age and sex on systemic versus organ-specific TH action and discuss their wider implication for clinical care.

Key words

age - sex - thyroid hormones - mouse models

Full Text

References

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