Mélissa Gruner et al. Narrow-band imaging versus Lugol chromoendoscopy for esophageal
squamous cell cancer screening in normal endoscopic practice: randomized controlled
trial
Narrow-band imaging (NBI) was compared with Lugol chromoendoscopy for the detection
of esophageal squamous carcinoma (SCC) and high grade dysplasia in 334 patients with
a history of SCC of the upper aerodigestive tract. In this randomized trial, specificity
for detection of lesions was greater with NBI than with Lugol. This outcome may have
been affected by the use of white-light endoscopy prior to NBI; however, this is compatible
with normal endoscopy practice.
