N-Acetyl-Cystein – Nur ein Mukolytikum?

Zusammenfassung

Durch die Spaltung von Disulfidbrücken wirkt N-Acetyl-Cystein (NAC) mukolytisch bei Atemwegs-/Lungenerkrankungen und greift die Hülle von SARS-CoV-2 an, wodurch die Infektiosität des neuen Coronavirus abgeschwächt wird. Als Gluthation-Prodrug hat die Substanz zentrale Bedeutung für Immunfunktion, Regulation der Stickstoffbilanz und Erhalt immunkompetenter Zellmasse. In einer Studie konnte eine Verbesserung der Überlebenszeitprognose von AIDS-Patienten unter NAC-Therapie belegt werden. Kardioprotektive Wirkung zeigt N-Acetyl-Cystein bei endothelialer Dysfunktion und Homocyst(e)inämie. Zudem konnte die Gabe von NAC in einer Studie kontrastmittelinduzierte Nierenschäden reduzieren.

Schlüsselwörter

N-Acety-Cystein Mukolytikum - Glutathion-Prodrug - L-Cystein, Lungenerkrankungen - COPD - Covid-19, Immunsystem - CG-Mangelsyndrom - AIDS - Kardioprotektion - Kontrastmittel

Publication History

Article published online:
14 October 2020

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