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Int J Sports Med 2021; 42(04): 307-313
DOI: 10.1055/a-1273-8304
Physiology & Biochemistr

Neuromuscular and Mobility Responses to a Vibration Session in Hypoxia in Multiple Sclerosis

Luis Andreu-Caravaca 
1   International Chair of Sports Medicine, Universidad Católica San Antonio de Murcia, Murcia
2   Faculty of Sport, Universidad Católica San Antonio de Murcia, Murcia
,
Linda H. Chung
3   UCAM Research Center for High Performance Sport, Universidad Católica San Antonio de Murcia, Murcia
,
Domingo Jesús Ramos-Campo
4   Sport Science, Universidad Catolica San Antonio de Murcia, Murcia
,
Elena Marín-Cascales
3   UCAM Research Center for High Performance Sport, Universidad Católica San Antonio de Murcia, Murcia
,
Alberto Encarnación-Martínez
5   Department of Physical Education and Sports, Research Group in Sport Biomechanics (GIBD), University of Valencia, Valencia
,
Jacobo Á Rubio-Arias
6   LFE Research Group, Department of Health and Human Performance, Universidad Politecnica de Madrid, Madrid
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Abstract

The aim of this study was to investigate the acute effects of vibration training (WBVT) under hypoxic and normoxic conditions on the voluntary rate of force development (RFD), balance and muscle oxygen saturation (SMO2) in persons with Multiple Sclerosis (MS). 10 participants completed the study (30% males, 44.4±7.7 years, 164.3±8.9 cm, 65.2±11.1 kg, 2.5±1.3 Expanded Disability Status Scale, 24.1±4.0 kg.m−2 BMI). Maximal force, RFD during isometric knee extension, static balance with eyes open and closed and sit-to-stand test were evaluated before and immediately after one session of WBVT (12 60-s bout of vibration; frequency 35 Hz; amplitude 4 mm; 1-min rest intervals) under both normoxic and hypoxic conditions. In addition, SMO2 of the gastrocnemius lateralis was assessed during each condition. No changes were found in force, static balance and sit-to-stand test. Time-to-peak RFD increased in the left leg (p=0.02) and tended to increase in the right leg (p=0.06) after the hypoxic session. SMO2 resulted in significant increases from the initial to final intervals of the WBVT under both hypoxic and normoxic conditions (p<0.05). Increases in SMO2 during WBVT demonstrates muscle work that may contribute to the observed muscle adaptations in long-term WBVT programs without inducing decreases in neuromuscular activation, physical function and balance within a session.

Key words

vibration training - neurological disorders - strength - muscle oxygenation - functional capacity

Supplementary Material



Publication History

Received: 07 May 2020

Accepted: 13 September 2020

Article published online:
19 October 2020

© 2021. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

  • References

  • 1 Barten LJ, Allington DR, Procacci KA. et al. New approaches in the management of multiple sclerosis. Drug Des Devel Ther 2010; 4: 343-366
    PubMedSearch in Google Scholar
  • 2 Browne P, Chandraratna D, Angood C. et al. Atlas of multiple sclerosis 2013: A growing global problem with widespread inequity. Neurology 2014; 83: 1022-1024
    CrossrefPubMedSearch in Google Scholar
  • 3 Martin CL, Phillips BA, Kilpatrick TJ. et al. Gait and balance impairment in early multiple sclerosis in the absence of clinical disability. Mult Scler 2006; 12: 620-628
    CrossrefPubMedSearch in Google Scholar
  • 4 Jørgensen MLK, Dalgas U, Wens I. et al. Muscle strength and power in persons with multiple sclerosis – a systematic review and meta-analysis. J Neurol Sci 2017; 376: 225-241
    CrossrefPubMedSearch in Google Scholar
  • 5 Thoumie P, Lamotte D, Cantalloube S. et al. Motor determinants of gait in 100 ambulatory patients with multiple sclerosis. Mult Scler 2005; 11: 485-491
    CrossrefPubMedSearch in Google Scholar
  • 6 de Silva R, Greenfield J, Cook A. et al. Guidelines on the diagnosis and management of the progressive ataxias. Orphanet J Rare Dis 2019; 14: 1-10
    CrossrefPubMedSearch in Google Scholar
  • 7 Motl RW. Ambulation and multiple sclerosis. Phys Med Rehabil Clin N Am 2013; 24: 325-336
    CrossrefPubMedSearch in Google Scholar
  • 8 Weideman AM, Tapia-Maltos MA, Johnson K. et al. Meta-analysis of the age-dependent efficacy of multiple sclerosis treatments. Front Neurol 2017; 8: 577
    CrossrefPubMedSearch in Google Scholar
  • 9 Amatya B, Khan F, Galea M. Rehabilitation for people with multiple sclerosis: An overview of Cochrane Reviews. Cochrane Database Syst Rev 2019; 1: CD012732
    PubMedSearch in Google Scholar
  • 10 Tae-Woon K, Yun-Hee S. Regular exercise promotes memory function and enhances hippocampal neuroplasticity in experimental autoimmune encephalomyelitis mice. Neuroscience 2017; 346: 173-181
    CrossrefPubMedSearch in Google Scholar
  • 11 White LJ, Castellano V. Exercise and brain health – implications for multiple sclerosis. Sports Med 2008; 38: 91-100
    CrossrefPubMedSearch in Google Scholar
  • 12 Motl RW, Pilutti LA. The benefits of exercise training in multiple sclerosis. Nat Rev Neurol 2012; 8: 487-497
    CrossrefPubMedSearch in Google Scholar
  • 13 Kantele S, Karinkanta S, Sievänen H. Effects of long-term whole-body vibration training on mobility in patients with multiple sclerosis: A meta-analysis of randomized controlled trials. J Neurol Sci 2015; 358: 31-37
    CrossrefPubMedSearch in Google Scholar
  • 14 Castillo-Bueno I, Ramos-Campo DJ, Rubio-Arias JA. Effects of whole-body vibration training in patients with multiple sclerosis: A systematic review. Neurologia 2018; 33: 534-548
    CrossrefPubMedSearch in Google Scholar
  • 15 Krause A, Gollhofer A, Freyler K. et al. Acute corticospinal and spinal modulation after whole body vibration. J Musculoskelet Neuronal Interact 2016; 16: 327-338
    PubMedSearch in Google Scholar
  • 16 Baudry S, Duchateau J. Independent modulation of corticospinal and group I afferents pathways during upright standing. Neuroscience 2014; 275: 162-169
    CrossrefPubMedSearch in Google Scholar
  • 17 Hodapp M, Vry J, Mall V. et al. Changes in soleus H-reflex modulation after treadmill training in children with cerebral palsy. Brain 2009; 132: 37-44
    CrossrefPubMedSearch in Google Scholar
  • 18 Hoque M, Borich M, Sabatier M. et al. Effects of downslope walking on Soleus H-reflexes and walking function in individuals with multiple sclerosis: A preliminary study. NeuroRehabilitation 2019; 44: 587-597
    CrossrefPubMedSearch in Google Scholar
  • 19 Maeda N, Urabe Y, Sasadai J. et al. Effect of whole-body-vibration training on trunk-muscle strength and physical performance in healthy adults: Preliminary results of a randomized controlled trial. J Sport Rehabil 2016; 25: 357-363
    CrossrefPubMedSearch in Google Scholar
  • 20 Schuhfried O, Mittermaier C, Jovanovic T. et al. Effects of whole-body vibration in patients with multiple sclerosis: A pilot study. Clin Rehabil 2005; 19: 834-842
    CrossrefPubMedSearch in Google Scholar
  • 21 Yang F, Finlayson M, Bethoux F. et al. Effects of controlled whole-body vibration training in improving fall risk factors among individuals with multiple sclerosis: A pilot study. Disabil Rehabil 2018; 40: 553-560
    CrossrefPubMedSearch in Google Scholar
  • 22 Wunderer K, Schabrun SM, Chipchase LS. Effects of whole body vibration on strength and functional mobility in multiple sclerosis. Physiother Theory Pract 2010; 26: 374-384
    CrossrefPubMedSearch in Google Scholar
  • 23 Mason RR, Cochrane DJ, Denny GJ. et al. Is 8 weeks of side-alternating whole-body vibration a safe and acceptable modality to improve functional performance in multiple sclerosis?. Disabil Rehabil 2012; 34: 647-654
    CrossrefPubMedSearch in Google Scholar
  • 24 Andreu L, Ramos-Campo DJ, Ávila-Gandía V. et al. Acute effects of whole-body vibration training on neuromuscular performance and mobility in hypoxia and normoxia in persons with multiple sclerosis: a crossover study. Mult Scler Relat Disord 2020; 37: 101454
    CrossrefPubMedSearch in Google Scholar
  • 25 Hilgers C, Mündermann A, Riehle H. et al. Effects of whole-body vibration training on physical function in patients with multiple sclerosis. NeuroRehabilitation 2013; 32: 655-663
    CrossrefPubMedSearch in Google Scholar
  • 26 Cochrane DJ, Stannard SR, Firth EC. et al. Acute whole-body vibration elicits post-activation potentiation. Eur J Appl Physiol 2010; 108: 311-319
    CrossrefPubMedSearch in Google Scholar
  • 27 Ramos-Campo DJ, Scott BR, Alcaraz PE. et al. The efficacy of resistance training in hypoxia to enhance strength and muscle growth: A systematic review and meta-analysis. Eur J Sport Sci 2018; 18: 92-103
    CrossrefPubMedSearch in Google Scholar
  • 28 Scott BR, Slattery KM, Sculley DV. et al. Hypoxia and resistance exercise: A comparison of localized and systemic methods. Sports Med 2014; 44: 1037-1054
    CrossrefPubMedSearch in Google Scholar
  • 29 Lundby C, Calbet JAL, Robach P. The response of human skeletal muscle tissue to hypoxia. Cell Mol Life Sci 2009; 66: 3615-3623
    CrossrefPubMedSearch in Google Scholar
  • 30 Zoll J, Ponsot E, Dufour S. et al. Exercise training in normobaric hypoxia in endurance runners. III. Muscular adjustments of selected gene transcripts. J Appl Physiol (1985) 2006; 100: 1258-1266
    CrossrefPubMedSearch in Google Scholar
  • 31 Casey DP, Joyner MJ. Compensatory vasodilatation during hypoxic exercise: Mechanisms responsible for matching oxygen supply to demand. J Physiol 2012; 590: 6321-6326
    Search in Google Scholar
  • 32 Ramos-Campo DJ, Rubio-Arias JA, Dufour S. et al. Biochemical responses and physical performance during high-intensity resistance circuit training in hypoxia and normoxia. Eur J Appl Physiol 2017; 117: 809-818
    CrossrefPubMedSearch in Google Scholar
  • 33 Scott BR, Slattery KM, Sculley DV. et al. Acute physiological responses to moderate-load resistance exercise in hypoxia. J Strength Cond Res 2017; 31: 1973-1981
    CrossrefPubMedSearch in Google Scholar
  • 34 Kon M, Ohiwa N, Honda A. et al. Effects of systemic hypoxia on human muscular adaptations to resistance exercise training. Physiol Rep 2014; 2: e12033
    CrossrefPubMedSearch in Google Scholar
  • 35 Britto FA, Gnimassou O, De Groote E. et al. Acute environmental hypoxia potentiates satellite cell-dependent myogenesis in response to resistance exercise through the inflammation pathway in human. FASEB J 2019; 34: 1-16
    PubMedSearch in Google Scholar
  • 36 World Medical Association. Declaration of Helsinki – Ethical principles for medical research involving human subjects (2000). Bull World Heal Organ 2001; 79: 373–374
  • 37 Harriss DJ, Macsween A, Atkinson G. Ethical standards in sport and exercise science research: 2020 update. Int J Sports Med 2019; 40: 813-817
    Thieme ConnectPubMedSearch in Google Scholar
  • 38 Thompson AJ, Banwell BL, Barkhof F. et al. Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria. Lancet Neurol 2018; 17: 162-173
    CrossrefPubMedSearch in Google Scholar
  • 39 Kantner RM, Rubin AM, Armstrong CW. et al. Stabilometry in balance assessment of dizzy and normal subjects. Am J Otolaryngol. 1991; 12: 196-204
    PubMedSearch in Google Scholar
  • 40 Ruiz-Cárdenas JD, Rodríguez-Juan JJ, Smart RR. et al. Validity and reliability of an iPhone App to assess time, velocity and leg power during a sit-to-stand functional performance test. Gait Posture 2018; 59: 261-266
    CrossrefPubMedSearch in Google Scholar
  • 41 Games KE, Sefton JEM, Wilson AE. Whole-body vibration and blood flow and muscle oxygenation: A meta-analysis. J Athl Train 2015; 50: 542-549
    CrossrefPubMedSearch in Google Scholar
  • 42 Yarar-Fisher C, Pascoe DD, Gladden LB. et al. Acute physiological effects of whole body vibration (WBV) on central hemodynamics, muscle oxygenation and oxygen consumption in individuals with chronic spinal cord injury. Disabil Rehabil 2014; 36: 136-145
    CrossrefPubMedSearch in Google Scholar
  • 43 Neary JP. Application of near infrared spectroscopy to exercise sports science. Can J Appl Physiol 2004; 29: 488-503
    CrossrefPubMedSearch in Google Scholar
  • 44 Subudhi AW, Dimmen AC, Roach RC. Effects of acute hypoxia on cerebral and muscle oxygenation during incremental exercise. J Appl Physiol (1985) 2007; 103: 177-183
    CrossrefPubMedSearch in Google Scholar
  • 45 Jackson KJ, Merriman HL, Vanderburgh PM. et al. Acute effects of whole-body vibration on lower extremity muscle performance in persons with multiple sclerosis. J Neurol Phys Ther 2008; 32: 171-176
    CrossrefPubMedSearch in Google Scholar
  • 46 Maffiuletti NA, Aagaard P, Blazevich AJ. et al. Rate of force development: physiological and methodological considerations. Eur J Appl Physiol 2016; 116: 1091-1116
    CrossrefPubMedSearch in Google Scholar
  • 47 Aagaard P, Suetta C, Caserotti P. et al. Role of the nervous system in sarcopenia and muscle atrophy with aging: Strength training as a countermeasure. Scand J Med. Sci Sport 2010; 20: 49-64
    PubMedSearch in Google Scholar
  • 48 Hess JA, Woollacott M, Shivitz N. Ankle force and rate of force production increase following high intensity strength training in frail older adults. Aging Clin Exp Res 2006; 18: 107-115
    CrossrefPubMedSearch in Google Scholar
  • 49 Rubenstein LZ. Falls in older people: epidemiology, risk factors and strategies for prevention. Age Ageing 2006; 35: 37-41
    CrossrefPubMedSearch in Google Scholar
  • 50 Buzaid A, Dodge MP, Handmacher L. et al. Activities of daily living. Evaluation and treatment in persons with multiple sclerosis. Phys Med Rehabil Clin N Am 2013; 24: 629-638
    CrossrefPubMedSearch in Google Scholar
  • 51 Gunn H, Markevics S, Haas B. et al. Systematic review: The effectiveness of interventions to reduce falls and improve balance in adults with multiple sclerosis. Arch Phys Med Rehabil 2015; 96: 1898-1912
    CrossrefPubMedSearch in Google Scholar
  • 52 Cruickshank TM, Reyes AR, Ziman MR. A systematic review and meta-analysis of strength training in individuals with multiple sclerosis or Parkinson disease. Medicine (Baltimore) 2015; 94: e411
    Search in Google Scholar
  • 53 Freitas EDS, Frederiksen C, Miller RM. et al. Acute and chronic effects of whole-body vibration on balance, postural stability, and mobility in women with multiple sclerosis. Dose-Response 2018; 16: 1-13
    PubMedSearch in Google Scholar
  • 54 Kjølhede T, Vissing K, Langeskov-Christensen D. et al. Relationship between muscle strength parameters and functional capacity in persons with mild to moderate degree multiple sclerosis. Mult Scler Relat Disord 2015; 4: 151-158
    CrossrefPubMedSearch in Google Scholar
  • 55 Taylor AD, Bronks R, Smith P. et al. Myoelectric evidence of peripheral muscle fatigue during exercise in severe hypoxia: Some references to m. vastus lateralis myosin heavy chain composition. Eur J Appl Physiol Occup Physiol 1997; 75: 151-159
    CrossrefPubMedSearch in Google Scholar
  • 56 de Oliveira FBD, Rizatto GF, Denadai BS. Are early and late rate of force development differently influenced by fast-velocity resistance training?. Clin Physiol Funct Imaging 2013; 33: 282-287
    CrossrefPubMedSearch in Google Scholar
  • 57 Ramos-Campo DJ, Rubio-Arias J, Freitas TT. et al. Acute physiological and performance responses to high-intensity resistance circuit training in hypoxic and normoxic conditions. J Strength Cond Res 2017; 31: 1040-1047
    CrossrefPubMedSearch in Google Scholar
  • 58 Scott BR, Slattery KM, Sculley DV. et al. Physical performance during high-intensity resistance exercise in normoxic and hypoxic conditions. J Strength Cond Res 2015; 29: 807-815
    CrossrefPubMedSearch in Google Scholar
  • 59 Mathew MW, Billaut F, Walker EJ. et al. Heavy resistance training in hypoxia enhances 1RM squat performance. Front Physiol 2016; 7: 502
    Search in Google Scholar
  • 60 Alashram AR, Padua E, Annino G. Effects of whole body vibration on motor impairments in patients with neurological disorders. Am J Phys Med Rehabil 2019; 98: 1084-1098
    CrossrefPubMedSearch in Google Scholar
  • 61 Hoang PD, Cameron MH, Gandevia SC. et al. Neuropsychological, balance, and mobility risk factors for falls in people with multiple sclerosis: a prospective cohort study. Arch Phys Med Rehabil 2014; 95: 480-486
    CrossrefPubMedSearch in Google Scholar
  • 62 Sosnoff JJ, Shin S, Motl RW. Multiple sclerosis and postural control: the role of spasticity. Arch Phys Med Rehabil 2010; 91: 93-99
    CrossrefPubMedSearch in Google Scholar
  • 63 Kanekar N, Lee YJ, Aruin AS. Frequency analysis approach to study balance control in individuals with multiple sclerosis. J Neurosci Methods 2014; 222: 91-96
    CrossrefPubMedSearch in Google Scholar
  • 64 Karst GM, Venema DM, Roehrs TG. et al. Center of pressure measures during standing tasks in minimally impaired persons with multiple sclerosis. J Neurol Phys Ther 2005; 29: 170-180
    CrossrefPubMedSearch in Google Scholar
  • 65 Van Emmerik REA, Remelius JG, Johnson MB. et al. Postural control in women with multiple sclerosis: effects of task, vision and symptomatic fatigue. Gait Posture 2010; 32: 608-614
    CrossrefPubMedSearch in Google Scholar
  • 66 Morrison S, Rynders CA, Sosnoff JJ. Deficits in medio-lateral balance control and the implications for falls in individuals with multiple sclerosis. Gait Posture 2016; 49: 148-154
    CrossrefPubMedSearch in Google Scholar
  • 67 Herrera WG. Vestibular and other balance disorders in multiple sclerosis. Differential diagnosis of disequilibrium and topognostic localization. Neurol Clin 1990; 8: 407-420
    PubMedSearch in Google Scholar
  • 68 Nelson SR, di Fabio RP, Anderson JH. Vestibular and sensory interaction deficits assessed by dynamic platform posturography in patients with multiple sclerosis. Ann Otol Rhinol Laryngol 1995; 104: 62-68
    CrossrefPubMedSearch in Google Scholar