Krankenhaushygiene up2date, Table of Contents Krankenhaushygiene up2date 2021; 16(04): 429-440DOI: 10.1055/a-1297-3709 Infektiologie Antibiotika – Einsatz und Resistenz in Human- und Veterinärmedizin Robin Köck Recommend Article Abstract Buy Article All articles of this category Der Einsatz von Antibiotika führt zur Selektion von Resistenzen. Komplex wird dieser Zusammenhang vor allem dann, wenn man verschiedene Reservoire wie die Veterinär- und Humanmedizin oder die Umwelt ganzheitlich betrachtet. Dieser Beitrag stellt Daten zum Antibiotika-Einsatz in der Human- und Veterinärmedizin zusammen, um sie vor dem Hintergrund ihres Potenzials zur Selektion multiresistenter Erreger zu analysieren. Full Text References Literatur 1 Davis CE, Anandan J. The evolution of r factor. A study of a „preantibiotic“ community in Borneo. N Engl J Med 1970; 282: 117-122 2 D’Costa VM, King CE, Kalan L. et al. Antibiotic resistance is ancient. Nature 2011; 477: 457-461 3 Bean DC, Livermore DM, Papa I. et al. Resistance among Escherichia coli to sulphonamides and other antimicrobials now little used in man. J Antimicrob Chemother 2005; 56: 962-964 4 White AC, Atmar RL, Wilson J. et al. Effects of requiring prior authorization for selected antimicrobials: expenditures, susceptibilities, and clinical outcomes. Clin Infect Dis 1997; 25: 230-239 5 Malhotra-Kumar S, Lammens C, Coenen S. et al. Effect of azithromycin and clarithromycin therapy on pharyngeal carriage of macrolide-resistant streptococci in healthy volunteers: a randomised, double-blind, placebo-controlled study. Lancet 2007; 369: 482-490 6 Berg HF, Tjhie JHT, Scheffer G-J. et al. Emergence and persistence of macrolide resistance in oropharyngeal flora and elimination of nasal carriage of Staphylococcus aureus after therapy with slow-release clarithromycin: a randomized, double-blind, placebo-controlled study. Antimicrob Agents Chemother 2004; 48: 4183-4188 7 Holstiege J, Schulz M, Akmatov MK. et al. The Decline in Outpatient Antibiotic Use. Dtsch Arztebl Int 2020; 117: 679-686 8 Schnepf A, Bienert-Zeit A, Ertugrul H. et al. Antimicrobial Usage in Horses: The Use of Electronic Data, Data Curation, and First Results. Front Vet Sci 2020; 7: 216 9 Tacconelli E, De Angelis G, Cataldo MA. et al. Antibiotic usage and risk of colonization and infection with antibiotic-resistant bacteria: a hospital population-based study. Antimicrob Agents Chemother 2009; 53: 4264-4269 10 Zhang Q, Lv L, Huang X. et al. Rapid increase in carbapenemase-producing Enterobacteriaceae in retail meat driven by the spread of the blaNDM-5-carrying IncX3 plasmid in China from 2016 to 2018. Antimicrob Agents Chemother 2019; 63 -19 11 Li J, Bi Z, Ma S. et al. Inter-host transmission of carbapenemase-producing Escherichia coli among humans and backyard animals. Environ Health Perspect 2019; 127: 107009 12 Wang Y, Lv Y, Cai J. et al. A novel gene, optrA, that confers transferable resistance to oxazolidinones and phenicols and its presence in Enterococcus faecalis and Enterococcus faecium of human and animal origin. J Antimicrob Chemother 2015; 70: 2182-2190 13 Liu B-G, Yuan X-L, He D-D. et al. Research progress on the oxazolidinone drug linezolid resistance. Eur Rev Med Pharmacol Sci 2020; 24: 9274-9281 14 Torres C, Alonso CA, Ruiz-Ripa L. et al. Antimicrobial Resistance in Enterococcus spp. of animal origin. Microbiol Spectr 2018; 6 15 Cuny C, Arnold P, Hermes J. et al. Occurrence of cfr-mediated multiresistance in staphylococci from veal calves and pigs, from humans at the corresponding farms, and from veterinarians and their family members. Vet Microbiol 2017; 200: 88-94 16 Klees S, Effelsberg N, Stührenberg B. et al. Prevalence and Epidemiology of Multidrug-Resistant Pathogens in the Food Chain and the Urban Environment in Northwestern Germany. Antibiotics (Basel) 2020; 9. doi 17 Köck R, Herr C, Kreienbrock L. et al. Multiresistant Gram-Negative Pathogens-A Zoonotic Problem. Dtsch Arztebl Int 2021; 118 18 Trung NV, Matamoros S, Carrique-Mas JJ. et al. Zoonotic Transmission of mcr-1 Colistin Resistance Gene from Small-Scale Poultry Farms, Vietnam. Emerging Infect Dis 2017; 23: 529-532 19 Cuny C, Layer F, Werner G. et al. State-wide surveillance of antibiotic resistance patterns and spa types of methicillin-resistant Staphylococcus aureus from blood cultures in North Rhine-Westphalia, 2011–2013. Clin Microbiol Infect 2015; 21: 750-757 20 Mughini-Gras L, Dorado-García A, van Duijkeren E. et al. Attributable sources of community-acquired carriage of Escherichia coli containing β-lactam antibiotic resistance genes: a population-based modelling study. Lancet Planet Health 2019; 3: e357-e369 21 Guidance for the rational use of antimicrobials (GRAM), Ceva Santé Animale. 2016 https://www.ava.com.au/siteassets/advocacy/gram-book---guidance-for-the-rational-use-of-antimicrobials.pdf am 13.10.2021 abgerufen