Using contrast-enhanced ultrasound in the diagnosis of hepatocellular carcinoma – what we have and have not achieved

• References

• 1 Strobel D, Seitz K, Blank W. et al Contrast-enhanced ultrasound for the characterization of focal liver lesions – diagnostic accuracy in clinical practice (DEGUM multicenter trial). Ultraschall in Med 2008; 29: 499-505
• 2 Seitz K, Greis C, Schuler A. et al Frequency of tumor entities among liver tumors of unclear etiology initially detected by sonography in the noncirrhotic or cirrhotic livers of 1349 patients. Results of the DEGUM multicenter study. Ultraschall in Med 2011. PMID: 22161557
• 3 Strobel D, Seitz K, Blank W. et al Tumor-specific vascularization pattern of liver me-tastasis, hepatocellular carcinoma, hemangioma and focal nodular hyperplasia in the differential diagnosis of 1,349 liver lesions in contrast-en-hanced ultrasound (CEUS). Ultraschall in Med 2009; 30 (04) 376-382 . https://doi.org/10.1055/s-0028-1109672
• 4 Tranquart F, Le Gouge A, Correas JM. et al Role of contrast-enhanced ultrasound in the blinded assessment of focal liver lesions in comparison with MDCT and CEMRI: results from a multicentre clinical trial. Eur J Cancer Suppl 2008; 6: 9-15
• 5 Trillaud H, Bruel JM, Valaette PJ. et al Characterization of focal liver lesions with SonoVue-enhanced sonography: international multicenter-study in comparison to CT and MRI. World J Gastroenterol 2009; 15: 3748-3756 . doi:10.3748/wjg.15.3748
• 6 Sporea I, Badea R, Popescu A. et al Contrast-enhanced ultrasound (CEUS) for the evaluation of focal liver lesions - a prospective multicenter study of its usefulness in clinical practice. Ultraschall in Med 2014; 35: 259-266 . doi:10.1055/s-0033-1355728. Epub 2014 Feb 21
• 7 Sporea I, Săndulescu DL, Şirli R. et al Contrast-Enhanced Ultrasound for the Characterization of Malignant versus Benign Focal Liver Lesions in a Prospective Multicenter Experience - The SRUMB Study. J Gastrointestin Liver Dis 2019; 28: 191-196 . doi:10.15403/jgld-180
• 8 Friedrich-Rust M, Klopffleisch T, Nierhoff J. et al Contrast-Enhanced Ultrasound for the differentiation of benign and malignant focal liver lesions: a meta-analysis. Liver Int 2013; 33: 739-755
• 9 Xie L, Guang Y, Ding H. et al Diagnostic value of contrast-enhanced ultrasound, computed tomography and magnetic resonance imaging for focal liver lesions: a meta-analysis. Ultrasound Med Biol 2011; 37: 854-861
• 10 Dietrich CF, Nolsøe CP, Barr RG. et al Guidelines and Good Clinical Practice Recommendations for Contrast Enhanced Ultrasound (CEUS) in the Liver – Update 2020 – WFUMB in Cooperation with EFSUMB, AFSUMB, AIUM, and FLAUS. Ultraschall in Med 2020; 41: 562-585 . doi:10.1055/a-1177-0530. Epub 2020 Jul 24
• 11 European Association for the Study of the Liver. EASL Clinical Practice Guidelines on the management of benign liver tumours. J Hepatol 2016; 65: 386-398
• 12 Piscaglia F, Bolondi L. Italian Society for Ultra-sound in Medicine and Biology (SIUMB) Study Group on Ultrasound Contrast Agents. The safety of Sonovue in abdominal applications: retrospective analysis of 23188 investigations. Ultrasound Med Biol 2006; 32: 1369-1375
• 13 Westwood M, Joore M, Grutters J. et al Contrast-enhanced ultrasound using SonoVue® (sulphur hexafluoride microbubbles) compared with contrast-enhanced computed tomography and contrast-enhanced magnetic resonance imaging for the characterisation of focal liver lesions and detection of liver metastases: a systematic review and cost-effectiveness analysis. Health Technol Assess 2013. PMID: 23611316 Free PMC article. Review
• 14 Niu Y, Huang T, Lian F. et al Contrast-enhanced ultrasonography for the diagnosis of small hepatocellular carcinoma: a meta-analysis and meta-regression analysis. Tumour Biol 2013; 34: 3667-3674
• 15 Chen LD, Xu HX, Xie XY. et al Intrahepatic cholangiocarcinoma and hepatocellular carcinoma: differential diagnosis with contrast-enhanced ultrasound. Eur Radiol 2010; 20: 743-753
• 16 Wildner D, Bernatik T, Greis C. et al CEUS in hepatocellular carcinoma and intrahepatic cholangiocellular carcinoma in 320 patients – early or late washout matters: a subanalysis of the DEGUM multicenter trial. Ultraschall in Med 2015; 36: 132-139
• 17 Marrero JA, Kulik LM, Sirlin CB. et al Diagnosis, Staging, and Management of HepatocellularCarcinoma: 2018 Practice Guidance by the American Association for the Study of Liver Diseases. Hepatology 2018; 68: 723-750
• 18 Omata M, Cheng AL, Kokudo N. et al Asia-Pacific clinical practice guidelineson the management of hepatocellularcarcinoma: a 2017 update. Hepatol Int 2017; 11: 317-370
• 19 Foerster F, Galle RP. Comparison of the current international guidelines on the management of HCC. JHEP Rep 2019; 1: 114-119
• 20 Galle PR, Forner A, Llovet JM. et al EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma. J Hepatol 2018; 69: 182-236
• 21 Greten TF, Malek NP, Schmidt S. et al Diagnosis of and therapy for hepatocellular carcinoma. Z Gastroenterol 2013; 51: 1269-1326
• 22 Schellhaas B, Strobel D. Tips and Tricks in Contrast-Enhanced Ultrasound (CEUS) for the Characterization andDetection of Liver Malignancies. Ultraschall in Med 2019; 40: 404-424
• 23 Kono Y, Lyshchik A, Cosgrove D. et al Contrast enhanced ultrasound (CEUS) liver imaging reporting and data system (LI-RADS®): the official version by the American College of radiology (ACR). Ultraschall in der Medizin-European Journal of Ultrasound 2017; 38: 85-86
• 24 Wilson SR, Lyshchik A, Piscaglia F. et al CEUS LI-RADS: algorithm, implementation, and key differences from CT/MRI. Abdom Radiol (NY) 2018; 43: 127-142
• 25 Piscaglia F, Wilson SR, Andrej Lyshchik A. et al American College of Radiology Contrast Enhanced Ultrasound Liver Imaging Reporting and Data System (CEUS LI-RADS) for the diagnosis of Hepatocellular Carcinoma: a pictorial essay. Ultraschall in Med 2017; 38: 320-324
• 26 Li J, Yang L, Ma L. et al Diagnostic Accuracy of Contrast-Enhanced Ultrasound Liver Imaging Reporting and Data System (CEUS LI-RADS) for Differentiating Between Hepatocellular Carcinoma and Other Hepatic Malignancies in High-Risk Patients: A Meta-Analysis. Ultraschall in Med [Online ahead of print]
• 27 Schellhaas B, Görtz RS, Pfeifer L. et al Diagnostic accuracy of contrast-enhanced ultrasound for the differential diagnosis of hepatocellular carcinoma: ESCULAP versus CEUS-LI-RADS. Eur J Gastroenterol Hepatol 2017; 29: 1036-1044
• 28 Schellhaas B, Pfeifer L, Kielisch C. et al Interobserver Agreement for Contrast-Enhanced Ultrasound (CEUS)-Based Standardized Algorithms for the Diagnosis of Hepatocellular Carcinoma in High-Risk Patients. Ultraschall in Med 2018; 39: 667-674
• 29 Schellhaas B, Hammon M, Strobel D. et al Interobserver and intermodality agreement of standardized algorithms for non-invasive diagnosis of hepatocellular carcinoma in high-risk patients: CEUS-LI-RADS versus MRI-LI-RADS. Eur Radiol 2018; 28: 4254-4264
• 30 Schellhaas B, Bernatik T, Bohle W. et al Contrast-Enhanced Ultrasound Algorithms (CEUS-LIRADS/ESCULAP) for the Noninvasive Diagnosis of Hepatocellular Carcinoma - A Prospective Multicenter DEGUM Study. Ultraschall in Med 2020;
• 31 Pfeifer L, Zopf S, Siebler J. et al Prospective Evaluation of Acoustic Radiation Force Impulse (ARFI) Elastography and High-Frequency B-Mode Ultrasound in Compensated Patients for the Diagnosis of Liver Fibrosis/Cirrhosis in Comparison to Mini-Laparoscopic Biopsy. Ultraschall in Med 2015; 36: 581-589
• 32 Cantisani V, Bertolotto M, Clevert DA. et al EFSUMB 2020 Proposal for a Contrast-Enhanced Ultrasound-Adapted Bosniak Cyst Categorization – Position Statement. Ultraschall in Med 2020; [Online ahead of print]