Recent Advances in the Synthesis of Heterocycles by the Aza-Wittig Reaction

Keyvan Pedrood; Mohammad Nazari Montazer; Bagher Larijani; Mohammad Mahdavi

doi:10.1055/a-1394-7511

Synthesis, Inhaltsverzeichnis

Synthesis 2021; 53(14): 2342-2366
DOI: 10.1055/a-1394-7511

short review

Recent Advances in the Synthesis of Heterocycles by the Aza-Wittig Reaction

Keyvan Pedrood

^aEndocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

,

Mohammad Nazari Montazer

^bDepartment of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran

,

Bagher Larijani

^aEndocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

,

Mohammad Mahdavi ∗

^aEndocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

› Institutsangaben

Abstract

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Abstract

The formation of the C=N bond in recent studies on heterocyclic compounds via the aza-Wittig reaction is reviewed. Furthermore, two different strategies for the formation of heterocyclic compounds, including intermolecular and intramolecular aza-Wittig reactions are described. The primary aim of this review is to provide up-to-date information on the application of the aza-Wittig reaction in the synthesis of a wide range of N-containing heterocyclic compounds in the chemical literature since 2010.

1 Introduction

2 Mechanism of the Staudinger and Aza-Wittig Reactions

3 Intramolecular Aza-Wittig Reaction

4 Intermolecular Aza-Wittig Reaction

5 Conclusion

Key words

aza-Wittig reaction - iminophosphorane - N-containing heterocycles - Staudinger reaction - cyclization

Volltext

Referenzen

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