Endobiliary radiofrequency ablation for ingrowth occlusion after bilateral metal stent placement in patients with malignant hilar biliary obstruction

Endobiliary radiofrequency ablation (RFA) can prolong the patency of bilateral metal stents (MS) in patients with malignant hilar biliary obstruction [1]. In addition, RFA is a potential treatment option for stent occlusion caused by ingrowth after MS placement [2]. However, there is no evidence of the feasibility of RFA in treating ingrowth after bilateral placement and the safety of repeated RFA remains unknown. Here, we describe a patient who underwent RFA reintervention for ingrowth occlusion after bilateral stent-by-stent (SBS) MS placement with RFA.

An 84-year-old woman with unresectable cholangiocarcinoma had undergone bilateral SBS placement using an uncovered MS (ZeoStent V, Zeon Medical, Tokyo, Japan), following RFA to the left and right hepatic duct strictures using Habib EndoHPB Catheter (Boston Scientific, Marlborough, Massachusetts, United States) and VIO300 D generator (ERBE Elektromedizin GmbH, Tubingen, Germany). Six months after the procedure, obstructive jaundice recurred due to stent occlusion; thus, we performed endoscopic reintervention. After biliary cannulation, two guidewires were advanced into the left and right intrahepatic bile ducts through each MS. A cholangioscope (SpyGlass DS; Boston Scientific) was subsequently inserted over the guidewire, and the cause of occlusion was determined to be an ingrowth in the hilar region. We then performed RFA to the ingrowth within each MS for 90 s at 7 W. Tissue debris was retrieved using a balloon catheter, and the stent lumen was successfully recanalized ( [Fig.1] and [Video 1]). The patient’s symptoms improved without adverse events, and the stents were patent during the follow-up period.

Fig. 1 a Cholangiography revealed strictures within previously placed metal stents in the hilar region due to ingrowth. b Radiofrequency ablation was performed of the ingrowth region within the right metal stent. c Radiofrequency ablation was performed of the ingrowth region within the left metal stent. d After the ablation, tissue debris was retrieved with a balloon catheter, and the stricture improved.

Video 1 Endobiliary radiofrequency ablation for ingrowth occlusion after bilateral stent-by-stent placement in a patient with malignant hilar biliary obstruction.

Conclusions

The management of stent occlusion after bilateral MS placement has not been established. Endobiliary RFA may be a useful option when treating ingrowth occlusion, especially after SBS placement.

Competing interests

Dr. Inoue received honoraria from Boston Scientific Japan and Japan Lifeline Co., Ltd, outside the submitted work.
The other authors disclose no financial relationships relevant to this publication.

• References

• 1 Inoue T, Ibusuki M, Kitano R. et al. Endobiliary radiofrequency ablation combined with bilateral metal stent placement for malignant hilar biliary obstruction. Endoscopy 2020; 52: 595-599
• 2 Kadayifci A, Atar M, Forcione DG. et al. Radiofrequency ablation for the management of occluded biliary metal stents. Endoscopy 2016; 48: 1096-1101

Publication History

Article published online:
27 May 2021