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DOI: 10.1055/a-1483-9865
Inhalant Abuse of Ethyl Chloride Spray: A Case Report
Inhalativer Missbrauch von Ethylchlorid-Spray: eine Fallstudie
Abstract
Ethyl chloride spray, which is usually used to relieve pain after injuries, is increasingly being used as a sniffing alternative. The number of people using this is rising due to its easy availability, cost-effectiveness and legality. The high lipid solubility of ethyl chloride leads to a rapid absorption of it in the lungs. However, data on the biotransformation of ethyl chloride in humans are sparse. We present the case of a 53-year-old male who had been inhaling ethyl chloride up to 3 times a week since 25 years, and describe his symptoms and the circumstances of abuse. This should help raise awareness of this issue so that abuse can be recognized early and rapid action taken.
Zusammenfassung
Ethylchlorid-Spray, das normalerweise zur Schmerzlinderung nach Verletzungen verwendet wird, wird zunehmend als Schnüffelalternative verwendet. Die Zahl steigt aufgrund der leichten Verfügbarkeit, der Kosteneffizienz und der Legalität. Aufgrund der hohen Fettlöslichkeit von Ethylchlorid kommt es zu einer raschen Absorption in der Lunge. Die Datenlage über die Biotransformation von Ethylchlorid beim Menschen ist jedoch begrenzt. Wir stellen den Fall eines 53-jährigen Mannes vor, der seit 25 Jahren bis zu 3-mal pro Woche Ethylchlorid inhaliert hat. Der vorgestellte Fall soll anhand der dargestellten Symptomen und Umständen das Bewusstsein für die Substanz erhöhen, um Missbrauch frühzeitig zu erkennen und ein schnelles Handeln zu gewährleisten.
Publication History
Received: 11 February 2020
Accepted: 08 April 2021
Article published online:
08 July 2021
© 2021. Thieme. All rights reserved.
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References
- 1 PubChem. National Center for Biotechnology Information. Chloroethane (27.03.2005) Im Internet https://pubchem.ncbi.nlm.nih.gov/compound/Chloroethane#section=Top/ Stand: 06.09.2019
- 2 Dreyhaupt FJ. VDI-Lexikon Umwelttechnik. p. 303). Heidelberg: Springer Verlag; 2013
- 3 Medical Subject Headings (MeSH). National Center for Biotechnology Information, U.S. National Library of Medicine 1999 Im Internet: https://toxnet.nlm.nih.gov/cgi-bin/sis/search/a?dbs+hsdb:@term+@DOCNO+533/ Stand: 01.10.2019.
- 4 Toxic Substances Portal. Agency for Toxic Substances & Disease Registry 2011 Im Internet: https://www.atscdc.gov/toxfaqs/tf.asp?id=826&tid=161/ Stand: 03.10.2019
- 5 Marelich GP. Volatile substance abuse. Clin Rev Allergy Immunol 1997; 15: 271-89
- 6 Barceloux DG. Medical Toxicology of Drug Abuse: Synthesized Chemicals and Psychoactive. Plants. (pp. 691–694). Hoboken, NJ: John Wiley & Sons; 2012
- 7 Kamaruddin NAS, Yacob AR. Detection of ethyl chloride abuse in urine sample. eProceedings. Chemistry 2 2017; 102-107
- 8 Nordin C, Rosenqvist M, Hollstedt C. Sniffing of ethyl chloride – an uncommon form of abuse with serious mental and neurological symptoms. Int J Addict 1988; 23 (06) 623-627
- 9 Soult TA, Walker JS. Ethyl chloride intoxication. Am J Emerg Med 1993; 11 (03) 313-315
- 10 Yacoub I, Robinson CA, Simmons GT, Hall M. Death attributed to ethyl chloride. J Anal Toxicol 1993; 17 (06) 384-385
- 11 Broussard LA, Broussard AK, Pittman TS. et al. Death due to inhalation of ethyl chloride. J Forensic Sci 2000; 45 (01) 223-225
- 12 Finch CK, Lobo BL. Acute inhalant-induced neurotoxicity with delayed recovery. Ann Pharmacother 2015; 39 (01) 169-172
- 13 Demarest C, Torqovnick J, Sethim NK. et al. Acute reversible neurotoxicity associated with inhalation of ethyl chloride: a case report. Clin Neurol Neurosurg 2011; 113 (10) 909-910
- 14 Demir M, Özdilek B, Domaç FM. et al. Ataxia Which Develops Due to Freeze Spray Abuse: A Case Study. Addicta: The Turkish Journal on Addictions 2015; 2 (02) 116-121
- 15 Senussi MH, Chalise S. Acute reversible neurological deficits due to ethyl chloride sniffing: a case report and review of literature. Am J Ther 2015; 22 (02) e40-42
- 16 Al-Ajmi AM, Morad MA, Cooper PE. et al. Reversible Ethyl Chloride Neurotoxicity: A Case Report. Can J Neurol Sci 2018; 45 (01) 119-120
- 17 Kuthiah N, Er C. “High” on Muscle Spray – Ethyl Chloride Abuse. Annals Academy of Medicine 2019; 48 (02) 67-68
- 18 National Toxicology Program. NTP Toxicology and Carcinogenesis Studies of Chloroethane (Ethyl Chloride) (CAS No. 75-00-3) in F344/N Rats and B6C3F1 Mice (Inhalation. Studies) 1989; 346: 1-161
- 19 U.S. Environmental Protection Agency. National Center for Environmental Assessment, Office of Research and Development. Integrated Risk Information System (IRIS) on Ethyl Chloride 1999 Im Internet https://cfpub.epa.gov/ncea/iris/iris_documents/documents/subst/0523_summary.pdf Stand: 19.10.2001
- 20 Agency for Toxic Substances and Diseases Registry (ATSDR). Toxicological Profile for Chloroethane (Update) 1998 Im Internet https://www.atscdc.gov/ToxProfiles/tp.asp?id=827&tid=161 Stand: 26.09.2019
- 21 Fedtke N, Certa H, Ebert R. et al. Species differences in the biotransformation of ethyl chloride. Archives of Toxicology 1994; 68 (03) 158-166
- 22 Scortichini BH, John-Greene JA, Quast JF. et al. Teratologic evaluation of dermally applied diethylene glycol monomethyl ether in rabbits. Fundam Appl Toxicol 1986; 7 (01) 68-75
- 23 Dell D, Hopkins C. Residential volatile substance misuse treatment for Indigenous youth in Canada. Substance Use & Misuse 2011; 46 (01) 107-113
- 24 Williams JF, Storck M. Inhalant abuse. Pediatrics 2007; 119 (05) 1009-1017
- 25 Baydala L. Inhalant abuse. Paediatr Child Health 2010; 15 (07) 443-448
- 26 Anderson CE, Loomis GA. Recognition and prevention of inhalant abuse. American Family Physician 2003; 68 (05) 869-874 https://www.aafp.org/afp/2003/0901/p869.html