Aza-Peterson Olefinations: Rapid Synthesis of (E)-Alkenes

Abstract

An aza-Peterson olefination methodology to access 1,3-dienes and stilbene derivatives from the corresponding allyl- or benzyltrimethylsilane is described. Silanes can be deprotonated using Schlosser’s base and added to N-phenyl imines or ketones to directly give the desired products in high yields.

Key words

Peterson olefination - imines - allylsilanes - Schlosser’s base - 1,3-dienes - stilbenes

Publication History

Received: 31 March 2021

Accepted after revision: 28 April 2021

Accepted Manuscript online:
28 April 2021

Article published online:
25 May 2021

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