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Synlett 2021; 32(13): 1253-1259
DOI: 10.1055/a-1493-9489
DOI: 10.1055/a-1493-9489
synpacts
Enantioselective Functionalization of Prochiral Cyclobutanones and Cyclobutenones
This work was supported by the National Natural Science Foundation of China (Grant Numbers 21772024 and 21921003).
Abstract
Enantioselective synthesis of cyclobutane derivatives is still a challenging topic in asymmetric synthesis. [2+2] Cycloaddition and skeleton rearrangement are two primary strategies to this end. Recently, functionalization of cyclobutanones and cyclobutenones, which are readily available via [2+2] cycloadditions as prochiral substrates, has emerged as a powerful tool to access versatile four-membered ring compounds. Herein, we summarize some recent advances in these areas from our and other groups.
1 Introduction
2 Enantioselective Functionalization of Cyclobutanones
2.1 Chiral Lithium Amide Approach
2.2 Enamine Approach
3 Enantioselective Functionalization of Cyclobutenones
4 Conclusion
Key words
cyclobutanone - cyclobutenone - desymmetrization - conjugate addition - chiral lithium amide - enantioselective reductionPublication History
Received: 01 April 2021
Accepted after revision: 28 April 2021
Accepted Manuscript online:
28 April 2021
Article published online:
25 May 2021
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