Intraventrikuläre Hirnblutungen des Frühgeborenen

Ulrich H. Thome; Matthias Knüpfer; Matthias Krause

doi:10.1055/a-1503-4222

Neuroradiologie Scan, Table of Contents

Neuroradiologie Scan 2021; 11(04): 269-282
DOI: 10.1055/a-1503-4222

CME-Fortbildung

Intraventrikuläre Hirnblutungen des Frühgeborenen

Pathophysiologie und Behandlung

Ulrich H. Thome

,

Matthias Knüpfer

,

Matthias Krause

Abstract

Frühgeborene haben im Vergleich zu Reifgeborenen ein erhöhtes Risiko für intrakranielle Blutungen, die das Ventrikelsystem und die umgebenden Strukturen betreffen. Das Risiko ist umso höher, je unreifer das Kind ist, und kann bei Kindern der 23.–24. Schwangerschaftswoche bis zu 50 % betragen. Wenn eine invasive Beatmung notwendig ist, erhöht sich ebenfalls das Risiko. Der Beitrag thematisiert Klassifikationssysteme und mögliche Therapien.

Schlüsselwörter

intraventrikuläre Hirnblutung - Ventrikelsystem - posthämorrhagischer Hydrozephalus - endoskopische Ventrikellavage

Full Text

References

Literatur
1 Ballabh P. Intraventricular hemorrhage in premature infants: mechanism of disease. Pediatr Res 2010; 67: 1-8
2 Osborn DA, Evans N, Kluckow M. Hemodynamic and antecedent risk factors of early and late periventricular/intraventricular hemorrhage in premature infants. Pediatrics 2003; 112: 33-39
3 Papile LA, Burstein J, Burstein R. et al. Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. J Pediatr 1978; 92: 529-534
4 Volpe JJ. Intraventricular hemorrhage in the premature infant – current concepts. Part II. Ann Neurol 1989; 25: 109-116
5 Deeg KH, Staudt F, von Rohden L. Blutungen des Frühgeborenen. Ultraschall in Med 1999; 20: 165-170
6 Bruschettini M, Romantsik O, Zappettini S. et al. Antithrombin for the prevention of intraventricular hemorrhage in very preterm infants. Coch Data Syst Rev 2016;
7 Dani C, Poggi C, Ceciarini F. et al. Coagulopathy screening and early plasma treatment for the prevention of intraventricular hemorrhage in preterm infants. Transfusion 2009; 49: 2637-2644
8 Hunt R, Hey E. Ethamsylate for the prevention of morbidity and mortality in preterm or very low birth weight infants. Coch Data Syst Rev 2010;
9 Knüpfer M, Ritter J, Pulzer F. et al. IVH in VLBW Preterm Babies – Therapy with Recombinant Activated F VII?. Klin Pädiatr 2017; 229: 335-341
10 Foglia EE, Roberts RS, Stoller JZ. et al. Trial of Indomethacin Prophylaxis in Preterms Investigators, Effect of Prophylactic Indomethacin in Extremely Low Birth Weight Infants Based on the Predicted Risk of Severe Intraventricular Hemorrhage. Neonatology 2018; 113: 183-186
11 Brouwer AJ, Groenendaal F, Benders MJNL. et al. Early and late complications of germinal matrix-intraventricular haemorrhage in the preterm infant: what is new?. Neonatology 2014; 106: 296-303
12 Aquilina K, Chakkarapani E, Thoresen M. Early deterioration of cerebrospinal fluid dynamics in a neonatal piglet model of intraventricular hemorrhage and posthemorrhagic ventricular dilation. J Neurosurg Pediatr 2012; 10: 529-537
13 Karimy JK, Zhang J, Kurland DB. et al. Inflammation-dependent cerebrospinal fluid hypersecretion by the choroid plexus epithelium in posthemorrhagic hydrocephalus. Nat Med 2017; 23: 997-1003
14 Gao F, Liu F, Chen Z. et al. Hydrocephalus after intraventricular hemorrhage: the role of thrombin. J Cereb Blood Flow Metab 2014; 34: 489-494
15 Park R, Moon UY, Park JY. et al. Yap is required for ependymal integrity and is suppressed in LPA-induced hydrocephalus. Nat Commun 2016; 7: 10329
16 Hladky SB, Barrand MA. Mechanisms of fluid movement into, through and out of the brain: evaluation of the evidence. Fluids Barriers CNS 2014; 11: 26
17 Abbott NJ. Evidence for bulk flow of brain interstitial fluid: significance for physiology and pathology. Neurochem Int 2004; 45: 545-552
18 Gao C, Du H, Hua Y. et al. Role of red blood cell lysis and iron in hydrocephalus after intraventricular hemorrhage. J Cereb Blood Flow Metab 2014; 34: 1070-1075
19 Garton T, Hua Y, Xiang J. et al. Keep, Challenges for intraventricular hemorrhage research and emerging therapeutic targets. Expert Opin Ther Targets 2017; 21: 1111-1122
20 Bir SC, Konar S, Maiti TK. et al. Outcome of ventriculoperitoneal shunt and predictors of shunt revision in infants with posthemorrhagic hydrocephalus. Childs Nerv Syst 2016; 32: 1405-1414
21 Verhaart WJC, Kramer W. The uncrossed pyramidal tract. Acta Psychiatr Neurol Scand 1952; 27: 181-200
22 Williams PTJA, Jiang Y-Q, Martin JH. Motor system plasticity after unilateral injury in the developing brain. Dev Med Child Neurol 2017; 59: 1224-1229
23 Weinstein M, Green D, Rudisch J. et al. Understanding the relationship between brain and upper limb function in children with unilateral motor impairments: A multimodal approach. Eur J Paediatr Neurol 2018; 22: 143-154
24 Chabrier S, Husson B, Dinomais M. et al. The Tich, New insights (and new interrogations) in perinatal arterial ischemic stroke. Thromb Res 2011; 127: 13-22
25 Whitelaw A, Aquilina K. Management of posthaemorrhagic ventricular dilatation. Arch Dis Child Fetal Neonatal Ed 2012; 97: F229-F223
26 Wang JY, Amin AG, Jallo GI. et al. Ventricular reservoir versus ventriculosubgaleal shunt for posthemorrhagic hydrocephalus in preterm infants: infection risks and ventriculoperitoneal shunt rate. J Neurosurg Pediatr 2014; 14: 447-454
27 Kim DK, Uttley D, Bell BA. et al. Moore, Comparison of rates of infection of two methods of emergency ventricular drainage. J Neurol Neurosurg Psy 1995; 58: 444-446
28 Whitelaw A, Lee-Kelland R. Repeated lumbar or ventricular punctures in newborns with intraventricular haemorrhage. Coch Data Syst Rev 2017; 4: CD000216
29 Mazzola CA, Choudhri AF, Auguste KI. et al. Pediatric Hydrocephalus Systematic Review and Evidence-Based Guidelines Task Force, Pediatric hydrocephalus: systematic literature review and evidence-based guidelines. Part 2: Management of posthemorrhagic hydrocephalus in premature infants. J Neurosurg Pediatr 2014; 14: 8-23
30 Wang Y-C, Lin C-W, Shen C-C. et al. Tissue plasminogen activator for the treatment of intraventricular hematoma: the dose-effect relationship. J Neurol Sci 2002; 202: 35-41
31 Gaberel T, Montagne A, Lesept F. et al. Urokinase versus Alteplase for intraventricular hemorrhage fibrinolysis. Neuropharmacology 2014; 85: 158-165
32 Tan Q, Chen Q, Niu Y. et al. Urokinase, a promising candidate for fibrinolytic therapy for intracerebral hemorrhage. J Neurosurg 2017; 126: 548-557
33 Whitelaw A, Pople I, Cherian S. et al. Phase-1-trial of prevention of hydrocephalus after intraventricular hemorrhage in newborn infants by drainage, irrigation, and fibrinolytic therapy. Pediatrics 2003; 111: 759-765
34 Whitelaw A, Jary S, Kmita G. et al. Pople, Randomized trial of drainage, irrigation and fibrinolytic therapy for premature infants with posthemorrhagic ventricular dilatation: developmental outcome at 2 years. Pediatrics 2010; 125: e852-e858
35 Luyt K, Jary S, Lea C. et al. Ten-year follow-up of a randomised trial of drainage, irrigation and fibrinolytic therapy (DRIFT) in infants with post-haemorrhagic ventricular dilatation. Health Technol Assess 2019; 23: 1-116
36 Schulz M, Bührer C, Pohl-Schickinger A. et al. Neuroendoscopic lavage for the treatment of intraventricular hemorrhage and hydrocephalus in neonates. J Neurosurg Pediatr 2014; 13: 626-635
37 D’Arcangues C, Schulz M, Bührer C. et al. Extended Experience with Neuroendoscopic Lavage for Posthemorrhagic Hydrocephalus in Neonates. World Neurosurg 2018; 116: e217-e224
38 Thomale U-W, Cinalli G, Kulkarni AV. et al. TROPHY registry study design: a prospective, international multicentre study for the surgical treatment of posthemorrhagic hydrocephalus in neonates. Childs Nerv Syst 2019; 35: 613-619