C–O-Selective Cross-Coupling of Chlorinated Phenol Derivatives

John E. A. Russell; Sharon R. Neufeldt

doi:10.1055/a-1503-6330

Synlett, Inhaltsverzeichnis

Synlett 2021; 32(15): 1484-1491
DOI: 10.1055/a-1503-6330

synpacts

C–O-Selective Cross-Coupling of Chlorinated Phenol Derivatives

John E. A. Russell

,

Sharon R. Neufeldt ∗

Abstract

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Abstract

Chemoselective cross-coupling of phenol derivatives is valuable for generating products that retain halides. Here we discuss recent developments in selective cross-couplings of chloroaryl phenol derivatives, with a particular focus on reactions of chloroaryl tosylates. The first example of a C–O-selective Ni-catalyzed Suzuki–Miyaura coupling of chloroaryl tosylates is discussed in detail.

1 Introduction

2 Density Functional Theory Studies on Oxidative Addition at Nickel(0)

3 Stoichiometric Oxidative Addition Studies

4 Development of a Tosylate-Selective Suzuki Coupling

5 Conclusion and Outlook

Key words

nickel catalysis - cross-coupling - oxidative addition - chemoselectivity - density functional theory - Suzuki–Miyaura coupling

Volltext

Referenzen

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