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Nervenheilkunde 2021; 40(08): 623-627
DOI: 10.1055/a-1516-1606
Schwerpunkt

Anti-Craving-Substanzen bei Alkoholabhängigkeit

Wirksamkeit und individuelle EinflussfaktorenAnti-craving substances and alcohol dependenceEffectiveness and individual influencing factors
Susanne Rösner∗
1   Forel Klinik, Ellikon an der Thur, Schweiz
,
Michael Soyka∗
2   Psychiatrische Klinik, Ludwig-Maximilians-Universität, München
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ZUSAMMENFASSUNG

Die Therapieerfolge von Anti-Craving-Substanzen bewegen sich im Bereich geringer bis moderater Effekte. Gleichzeitig macht die starke Heterogenität der Effekte innerhalb von Studien deutlich, dass sich Patienten im Ansprechen auf Anti-Craving-Substanzen unterscheiden und in bestimmten Patientengruppen stärkere Effekte als im Stichprobenmittel erzielt werden. Eine daraus ableitbare therapeutische Strategie basiert auf der Individualisierung der pharmakologischen Rückfallprophylaxe unter Berücksichtigung der zugrunde liegenden Wirkmechanismen [1]. Ein weiterer Ansatz besteht in der Modifikation von Faktoren, die für das Ansprechen von Patienten von Bedeutung sind. Voraussetzung dafür ist die Identifikation individueller Einflussfaktoren und die Etablierung von Methoden, diese in positiver Richtung zu verändern.

Der folgende Beitrag gibt einen Überblick über die aktuelle Befundlage zur Wirksamkeit von Anti-Craving-Substanzen, wobei der Schwerpunkt auf die Darstellung individueller Effektmoderatoren als Grundlage für die Ableitung optimierender Strategien gelegt wird.

Abstract

Effects of anti-craving-drugs range from low to moderate effect sizes. At the same time, the heterogeneity of effects indicates that patients respond different to the effects of anti-craving-drugs with certain patient subgroups benefiting more than others. Deducible relapse prevention strategies include the individualization of pharmacological strategies under consideration of the underlying mechanism of action [1]. A further option to increase effects is to modify individual factors that determine patients’ subjective response to anti-craving-drugs. This requires the identification of individual response predictors and the establishment of methods to modify them in a positive direction.

The publication at hand provides an overview of findings on the effectiveness of anti-craving-drugs focusing individual moderators of effectiveness as a base for deducing strategies for its modification.

Schlüsselwörter

Alkohol - Anti-Craving-Substanzen - individuelles Ansprechen

Key words

Alcohol - anti-craving substances - subjective response


Publication History

Article published online:
04 August 2021

© 2021. Thieme. All rights reserved.

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