Aminothiaindanone as an Accessible Scaffold for a Three-Point Chemical Diversity

Abstract

Aminothiaindanone heterocycle appears to be a scaffold of interest in medicinal chemistry. To increase the chemical diversity in this series, the introduction of three-point chemical diversity on the cyclopenta[b]thiophen-4-one scaffold was explored. About thirty newly functionalized thiophene-containing bicycles were obtained using various chemical reactions, paving the way for novel possibilities in medicinal chemistry projects.

Key words

aminothiaindanone - functionalization - thiophene - multi-step synthesis

• References

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