Notaufnahme up2date 2023; 05(01): 41-58
DOI: 10.1055/a-1526-4777
Thorax, Herz und Atemwege

Das akute Aortensyndrom

Artis Knapsis
1   Klinik für Gefäß- und Endovaskularchirurgie, Universitätsklinikum Düsseldorf, Düsseldorf, Deutschland
,
Jan David Süss
1   Klinik für Gefäß- und Endovaskularchirurgie, Universitätsklinikum Düsseldorf, Düsseldorf, Deutschland
› Author Affiliations

Zum akuten Aortensyndrom, das eine Konstellation lebensbedrohlicher Aortenwanderkrankungen beschreibt, zählen als Hauptentitäten die Aortendissektion, das intramurale Hämatom und das penetrierende Aortenulkus. Das Leitsymptom dieser Erkrankungen ist der akute Thoraxschmerz. Häufig sind die Symptome aber unspezifisch. Dadurch wird die Diagnosestellung in der Zentralen Notaufnahme erschwert. Eine rechtzeitige Diagnostik und Therapie sind für die Prognose des Patienten entscheidend.

Kernaussagen
  • Das akute Aortensyndrom ist eine potenziell lebensbedrohliche Erkrankung, die schnell diagnostiziert und therapiert werden muss.

  • Die häufigste Entität des akuten Aortensyndroms ist die Aortendissektion.

  • Die CT-Angiografie ist der Goldstandard der Diagnostik.

  • Die Patienten müssen bereits in der Notaufnahme hämodynamisch überwacht werden.

  • Das Initialmanagement besteht aus Analgesie (Opiate) und antihypertensiver Therapie mit intravenösen Betablockern und Nitraten.

  • Eine Typ-A-Aortendissektion muss unmittelbar chirurgisch therapiert werden.

  • Die unkomplizierte AD, IMH und PAU können konservativ behandelt werden.

  • Alle Patienten mit der Diagnose AAS müssen in ein Zentrum mit Expertise für thorakale Aortenpathologien verlegt werden.



Publication History

Article published online:
10 January 2023

© 2022. Thieme. All rights reserved.

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  • Literatur

  • 1 Nienaber CA, Eagle KA. Aortic dissection: new frontiers in diagnosis and management: Part I: from etiology to diagnostic strategies. Circulation 2003; 108: 628-635
  • 2 Nienaber CA. Acute aortic syndrome. Dtsch Med Wochenschr 2016; 141: 752-756
  • 3 Wurster T, Riessen R, Haap M. Acute aortic syndrome. Dtsch Med Wochenschr 2015; 140: 104-109
  • 4 Czerny M, Schmidli J, Adler S. et al. Current options and recommendations for the treatment of thoracic aortic pathologies involving the aortic arch: an expert consensus document of the European Association for Cardio-Thoracic surgery (EACTS) and the European Society for Vascular Surgery (ESVS). Eur J Cardiothorac Surg 2019; 55: 133-162
  • 5 Riambau V, Böckler D, Brunkwall J. et al. Editor's Choice – Management of Descending Thoracic Aorta Diseases: Clinical Practice Guidelines of the European Society for Vascular Surgery (ESVS). Eur J Vasc Endovasc Surg 2017; 53: 4-52
  • 6 Erbel R, Aboyans V, Boileau C. et al. 2014 ESC Guidelines on the diagnosis and treatment of aortic diseases: Document covering acute and chronic aortic diseases of the thoracic and abdominal aorta of the adult. The Task Force for the Diagnosis and Treatment of Aortic Diseases of the European Society of Cardiology (ESC). Eur Heart J 2014; 35: 2873-2926
  • 7 Pape LA, Awais M, Woznicki EM. et al. Presentation, Diagnosis, and Outcomes of Acute Aortic Dissection: 17-Year Trends From the International Registry of Acute Aortic Dissection. J Am Coll Cardiol 2015; 66: 350-358
  • 8 Clouse WD, Hallett Jr JW, Schaff HV. et al. Acute aortic dissection: population-based incidence compared with degenerative aortic aneurysm rupture. Mayo Clin Proc 2004; 79: 176-180
  • 9 Hiratzka LF, Bakris GL, Beckman JA. et al. 2010 ACCF/AHA/AATS/ACR/ASA/SCA/SCAI/SIR/STS/SVM guidelines for the diagnosis and management of patients with Thoracic Aortic Disease: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines, American Association for Thoracic Surgery, American College of Radiology, American Stroke Association, Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, Society of Interventional Radiology, Society of Thoracic Surgeons, and Society for Vascular Medicine. Circulation 2010; 121: e266-369
  • 10 Nienaber CA, Fattori R, Mehta RH. et al. Gender-related differences in acute aortic dissection. Circulation 2004; 109: 3014-3021
  • 11 DeMartino RR, Sen I, Huang Y. et al. Population-Based Assessment of the Incidence of Aortic Dissection, Intramural Hematoma, and Penetrating Ulcer, and Its Associated Mortality From 1995 to 2015. Circ Cardiovasc Qual Outcomes 2018; 11: e004689
  • 12 Mussa FF, Horton JD, Moridzadeh R. et al. Acute Aortic Dissection and Intramural Hematoma: A Systematic Review. JAMA 2016; 316: 754-763
  • 13 Evangelista A, Mukherjee D, Mehta RH. et al. Acute intramural hematoma of the aorta: a mystery in evolution. Circulation 2005; 111: 1063-1070
  • 14 Hagan PG, Nienaber CA, Isselbacher EM. et al. The International Registry of Acute Aortic Dissection (IRAD): new insights into an old disease. JAMA 2000; 283: 897-903
  • 15 Li W, Huang B, Tian L. et al. Admission D-dimer testing for differentiating acute aortic dissection from other causes of acute chest pain. Arch Med Sci 2017; 13: 591-596
  • 16 Shimony A, Filion KB, Mottillo S. et al. Meta-analysis of usefulness of d-dimer to diagnose acute aortic dissection. Am J Cardiol 2011; 107: 1227-1234
  • 17 Rogers AM, Hermann LK, Booher AM. et al. Sensitivity of the aortic dissection detection risk score, a novel guideline-based tool for identification of acute aortic dissection at initial presentation: results from the international registry of acute aortic dissection. Circulation 2011; 123: 2213-2218
  • 18 Tsutsumi Y, Tsujimoto Y, Takahashi S. et al. Accuracy of aortic dissection detection risk score alone or with D-dimer: A systematic review and meta-analysis. Eur Heart J Acute Cardiovasc Care 2020; 9: S32-S39
  • 19 Diercks DB, Promes SB, Schuur JD. et al. Clinical policy: critical issues in the evaluation and management of adult patients with suspected acute nontraumatic thoracic aortic dissection. Ann Emerg Med 2015; 65: 32-42.e12
  • 20 Nazerian P, Mueller C, Soeiro AM. et al. Diagnostic Accuracy of the Aortic Dissection Detection Risk Score Plus D-Dimer for Acute Aortic Syndromes: The ADvISED Prospective Multicenter Study. Circulation 2018; 137: 250-258
  • 21 Morello F, Bima P, Pivetta E. et al. Development and Validation of a Simplified Probability Assessment Score Integrated With Age-Adjusted d-Dimer for Diagnosis of Acute Aortic Syndromes. J Am Heart Assoc 2021; 10: e018425
  • 22 Gulati M, Levy PD, Mukherjee D. et al. 2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR Guideline for the Evaluation and Diagnosis of Chest Pain: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. J Am Coll Cardiol 2021; 78: e187-e285
  • 23 Goldstein SA, Evangelista A, Abbara S. et al. Multimodality imaging of diseases of the thoracic aorta in adults: from the American Society of Echocardiography and the European Association of Cardiovascular Imaging: endorsed by the Society of Cardiovascular Computed Tomography and Society for Cardiovascular Magnetic Resonance. J Am Soc Echocardiogr 2015; 28: 119-182
  • 24 Bossone E, Evangelista A, Isselbacher E. et al. Prognostic role of transesophageal echocardiography in acute type A aortic dissection. Am Heart J 2007; 153: 1013-1020
  • 25 Rogers IS, Banerji D, Siegel EL. et al. Usefulness of comprehensive cardiothoracic computed tomography in the evaluation of acute undifferentiated chest discomfort in the emergency department (CAPTURE). Am J Cardiol 2011; 107: 643-650
  • 26 Shiga T, Wajima Zi, Apfel CC. et al. Diagnostic Accuracy of Transesophageal Echocardiography, Helical Computed Tomography, and Magnetic Resonance Imaging for Suspected Thoracic Aortic Dissection: Systematic Review and Meta-analysis. Arch Intern Med 2006; 166: 1350-1356
  • 27 Wheat Jr MW, Palmer RF, Bartley TD. et al. Treatment of Dissecting Aneurysms of the Aorta without Surgery. J Thorac Cardiovasc Surg 1965; 50: 364-373
  • 28 Rushmer RF. Initial ventricular impulse. A potential key to cardiac evaluation. Circulation 1964; 29: 268-283
  • 29 Bossone E, LaBounty TM, Eagle KA. Acute aortic syndromes: diagnosis and management, an update. Eur Heart J 2018; 39: 739-749d
  • 30 Krenz JR, O'Brien ME, Lee J. et al. Evaluation of esmolol for heart rate control in patients with acute aortic dissection. Am J Emerg Med 2021; 44: 312-314
  • 31 Williams B, Mancia G, Spiering W. et al. 2018 ESC/ESH Guidelines for the management of arterial hypertension. Eur Heart J 2018; 39: 3021-3104
  • 32 Zeeshan A, Woo EY, Bavaria JE. et al. Thoracic endovascular aortic repair for acute complicated type B aortic dissection: superiority relative to conventional open surgical and medical therapy. J Thorac Cardiovasc Surg 2010; 140: S109-115
  • 33 Oberhuber A, Maßmann A, Betge S. et al. Leitlinie-S2K Typ B Aortendissektion 004–034. https://register.awmf.org/assets/guidelines/004–034l_S2k_Typ_B_Aortendissektion_2022–05.pdf