Recapitulation of Evidence of Phytochemical, Pharmacokinetic and
                    Biomedical Application of Silybin

Anas Islam; Anuradha Mishra; Md Aftab Siddiqui; Saman Siddiquie

doi:10.1055/a-1528-2721

Drug Research, Table of Contents

Drug Res (Stuttg) 2021; 71(09): 489-503
DOI: 10.1055/a-1528-2721

Review

Recapitulation of Evidence of Phytochemical, Pharmacokinetic and Biomedical Application of Silybin

Anas Islam

¹Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India

,

Anuradha Mishra

¹Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India

,

Md Aftab Siddiqui

¹Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India

,

Saman Siddiquie

¹Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India

› Author Affiliations

Abstract

Silymarin is a standardized extract obtained from seeds of Silybum marianum (SM) belonging to the family Asteraceae. It is a flavonolignan complex and consists of various compounds like silybin A silybin B, isosilybin A, isosilybin B, silydianin, silychristin and isosilychristin. Silybin is the major active component present in 60–70% of the silymarin extract. It has been used traditionally for the treatment of various liver disorders like cirrhosis, jaundice, and hepatitis. Silymarin possesses antioxidant and anti-inflammatory properties and is responsible for its antitumor activity. Other than hepatoprotective effect SM also possesses renoprotective, anti-diabetic, neuroprotective, hypolipidemic, anti-atherosclerosis and cardioprotective effects. Rather antimicrobial property of silymarin was observed against specific microbes, fungi, and viruses. This manuscript covered recent preclinical and clinical evidence of specific components silybin, responsible for its efficacy and about clinical studies has been conducted so far, which proven it’s safety and offers mild effect like nausea, diarrhea and bloating. This review specifically focused on recent updates on its active components therapeutic applications against complicated ailments not covered in earlier reports.

Key words

Silybum marianum - Silybin - flavonolignan - therapeutic - clinical

Full Text

References

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