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Dtsch Med Wochenschr 2021; 146(18): 1218-1225
DOI: 10.1055/a-1529-4521
Übersicht

Typ-2-Diabetes-mellitus und Krebsrisiko

Type-2-diabetes and cancer risk
Hans Scherübl
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Typ-2-Diabetes-mellitus-Patienten sterben heute am häufigsten an Krebs. In Dickdarm, Bauchspeicheldrüse, Gallenblase, Leber, Magen und vielen weiteren Geweben können sich T2D-assoziierte Malignomen bilden. Weitere Faktoren, wie z. B. Tabakkonsum, Bewegungsmangel und Übergewicht, erhöhen das Risiko. Menschen mit Typ-2-Diabetes sollten deshalb frühzeitig und regelmäßig zur Teilnahme an etablierten Krebsfrüherkennungsmaßnahmen eingeladen werden.

Abstract

Type-2-diabetes (T2D) increases the risk for several cancers and cancer has become the major cause of death of T2D-patients. T2D is causally associated with colorectal, pancreatic, gallbladder, biliary, hepatocellular, gastric, esophageal, oral, breast, endometrial, ovary, kidney and thyroid cancers as well as leukemias. When T2D goes along with tobacco smoking, alcohol use, physical inactivity, excess body weight, poor diet, familial risk or certain chronic infections, the cumulative cancer risk rises, and T2D-patients often suffer from cancer disease at younger age. T2D-patients should be encouraged to join cancer screening programmes even at younger age than the average non-diabetic population.

Schlüsselwörter

Tumor - Krebs - Neoplasie - Mund - Speiseröhre - Magen - Pankreas - Leber - Gallenwege - Gallenblase - Dickdarm - Niere - Brust - Endometrium - Eierstöcke - Schilddrüse - Leukämie - Vorsorge - Früherkennung - Präzisionsmedizin - Diabetes - Screening - Prävention

Key words

tumor - cancer - neoplasia - mouth - esophagus - stomach - pancreas - liver - bile duct - gallbladder - colon - rectum - kidney - breast - endometrium - ovary - thyroid - leukemia - prevention - screening - early detection - diabetes - precision medicine


Publication History

Article published online:
14 September 2021

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