Noziplastischer Schmerz – Neue Erkenntnisse aus der klinischen Forschung

Lange unterschied man Schmerzen in nozizeptiv und neuropathisch. Als klar war, dass sich viele Schmerzmechanismen nicht rein gewebspathologisch betrachten lassen, beschrieb eine Forschungsgruppe eine dritte Kategorie, den noziplastischen Schmerz. Zudem veröffentlichte sie einen Leitfaden, um die Wahrscheinlichkeit noziplastischer Mechanismen zu beurteilen.

Publication History

Article published online:
18 October 2021

• Literaturverzeichnis

• 1 Terminology | International Association for the Study of Pain. International Association for the Study of Pain (IASP). Im Internet: https://www.iasp-pain.org/resources/terminology/ letzter Zugriff am 11.8.2021.
• 2 Kosek E, Cohen M, Baron R. et al Do we need a third mechanistic descriptor for chronic pain states. Pain 2016; 157: 1382-1386
• 3 Jensen TS, Baron R, Haanpää M. et al A new definition of neuropathic pain. Pain 2011; 152: 2204-2205
• 4 Brinjikji W, Luetmer PH, Comstock B. et al Systematic Literature Review of Imaging Features of Spinal Degeneration in Asymptomatic Populations. Am J Neuroradiol 2015; 36: 811-816
• 5 Barreto RPG, Braman JP, Ludewig PM. et al Bilateral magnetic resonance imaging findings in individuals with unilateral shoulder pain. J Shoulder Elbow Surg 2019; 28: 1699-1706
• 6 Granan L-P. We do not need a third mechanistic descriptor for chronic pain states! Not yet. Pain 2017; 158: 179
• 7 Brummett C, Clauw D, Harris R. et al We agree with the need for a new term but disagree with the proposed terms. Pain 2016; 157: 2876
• 8 Fitzcharles M-A, Cohen SP, Clauw DJ. et al Nociplastic pain: towards an understanding of prevalent pain conditions. Lancet Lond Engl 2021; 397: 2098-1210
• 9 Kosek E, Clauw D, Nijs J. et al Chronic nociplastic pain affecting the musculoskeletal system: clinical criteria and grading system. Pain 2021;
• 10 Trouvin A-P, Perrot S. New concepts of pain. Best Pract Res Clin Rheumatol 2019; 33: 101415
• 11 Luomajoki H, Schesser R. Schmerzmechanismen und Clinical Reasoning. Schmerzpatient 2021; 4: 126-41
• 12 Lewis GN, Parker RS, Sharma S. et al Structural Brain Alterations Before and After Total Knee Arthroplasty: A Longitudinal Assessment. Pain Med Malden Mass 2018; 19: 2166-2176
• 13 Kosek E, Ordeberg G. Abnormalities of somatosensory perception in patients with painful osteoarthritis normalize following successful treatment. Eur J Pain Lond Engl 2000; 4: 229-238
• 14 Fernández-Carnero J, Fernández-de-las-Peñas C, de la Llave-Rincón AI. et al Widespread Mechanical Pain Hypersensitivity as Sign of Central Sensitization in Unilateral Epicondylalgia: A Blinded Controlled Study. Clin J Pain 2009; 25: 555-561
• 15 Nijs J, Lahousse A, Kapreli E. et al Nociplastic Pain Criteria or Recognition of Central Sensitization? Pain Phenotyping in the Past, Present and Future. J Clin Med 2021; 10: 3203
• 16 Ferro Moura Franco K, Lenoir D, Dos Santos Franco YR. et al Prescription of exercises for the treatment of chronic pain along the continuum of nociplastic pain: A systematic review with meta-analysis. Eur J Pain Lond Engl 2021; 25: 51-70
• 17 Nijs J, George SZ, Clauw DJ. et al Central sensitisation in chronic pain conditions: latest discoveries and their potential for precision medicine. Lancet Rheumatol 2021; 3: e383-392
• 18 Klaf A. THE HIGHJACKING OF “NOCIPLASTIC”. PAINLOSOPHY; 2016. Im Internet https://painlosophy.wordpress.com/2021/06/08/the-highjacking-of-nociplastic/ letzter Zugriff am 11.8.2021.