Die frühzeitige Diagnose und Therapie von tiefen Venenthrombosen vermindern das Risiko für eine Lungenembolie und ein postthrombotisches Syndrom. In diesem Beitrag wird erklärt, welche Schritte für die Diagnosestellung von Bedeutung sind und welche Ursachen der tiefen Venenthrombose zugrunde liegen können.
Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, Germany
Literatur
1
Goodacre S,
Sutton AJ,
Sampson FC.
Meta-analysis: The value of clinical assessment in the diagnosis of deep venous thrombosis. Ann Intern Med 2005; 143: 129-139
3
Wells PS,
Anderson DR,
Rodger M.
et al. Evaluation of D-dimer in the diagnosis of suspected deep-vein thrombosis. The New England journal of medicine 2003; 349: 1227-1235
4
Aguilar C,
del Villar V.
Diagnostic performance of D-dimer is lower in elderly outpatients with suspected deep venous thrombosis. Br J Haematol 2005; 130: 803-804 author reply 805
5
Schouten HJ,
Geersing GJ,
Koek HL.
et al. Diagnostic accuracy of conventional or age adjusted D-dimer cut-off values in older patients with suspected venous thromboembolism: systematic review and meta-analysis. BMJ 2013; 346: f2492
6
Righini M,
Van Es J,
Den Exter PL.
et al. Age-adjusted D-dimer cutoff levels to rule out pulmonary embolism: the ADJUST-PE study. JAMA 2014; 311: 1117-1124
7
Farm M,
Siddiqui AJ,
Onelov L.
et al. Age-adjusted D-dimer cut-off leads to more efficient diagnosis of venous thromboembolism in the emergency department: a comparison of four assays. J Thromb Haemost 2018; 16: 866-875
9
Mateo J,
Oliver A,
Borrell M.
et al. Laboratory evaluation and clinical characteristics of 2,132 consecutive unselected patients with venous thromboembolism-results of the Spanish Multicentric Study on Thrombophilia (EMET-Study). Thromb Haemost 1997; 77: 444-451
10
Margaglione M,
Brancaccio V,
Giuliani N.
et al. Increased risk for venous thrombosis in carriers of the prothrombin G->A20210 gene variant. Ann Intern Med 1998; 129: 89-93
11
Crowther MA,
Kelton JG.
Congenital thrombophilic states associated with venous thrombosis: a qualitative overview and proposed classification system. Ann Intern Med 2003; 138: 128-134
16
Heit JA,
O’Fallon WM,
Petterson TM.
et al. Relative impact of risk factors for deep vein thrombosis and pulmonary embolism: a population-based study. Arch Intern Med 2002; 162: 1245-1248
17
Bauer KA.
Venous thromboembolism in malignancy. Journal of clinical oncology: official journal of the American Society of Clinical Oncology 2000; 18: 3065-3067
18
Elting LS,
Escalante CP,
Cooksley C.
et al. Outcomes and cost of deep venous thrombosis among patients with cancer. Arch Intern Med 2004; 164: 1653-1661
19
Prandoni P,
Lensing AW,
Buller HR.
et al. Deep-vein thrombosis and the incidence of subsequent symptomatic cancer. The New England journal of medicine 1992; 327: 1128-1133
20
Douketis JD,
Gu C,
Piccioli A.
et al. The long-term risk of cancer in patients with a first episode of venous thromboembolism. J Thromb Haemost 2009; 7: 546-551
22
Ocak G,
Vossen CY,
Verduijn M.
et al. Risk of venous thrombosis in patients with major illnesses: results from the MEGA study. J Thromb Haemost 2013; 11: 116-123
23
Peragallo Urrutia R,
Coeytaux RR,
McBroom AJ.
et al. Risk of acute thromboembolic events with oral contraceptive use: a systematic review and meta-analysis. Obstet Gynecol 2013; 122: 380-389
24
Stegeman BH,
de Bastos M,
Rosendaal FR.
et al. Different combined oral contraceptives and the risk of venous thrombosis: systematic review and network meta-analysis. BMJ 2013; 347: f5298
25
Bloemenkamp KW,
Rosendaal FR,
Helmerhorst FM.
et al. Higher risk of venous thrombosis during early use of oral contraceptives in women with inherited clotting defects. Arch Intern Med 2000; 160: 49-52
26
Roach RE,
Lijfering WM,
Helmerhorst FM.
et al. The risk of venous thrombosis in women over 50 years old using oral contraception or postmenopausal hormone therapy. J Thromb Haemost 2013; 11: 124-131
