Fette runter mit Omega-3? – Der Einfluss von Omega-3-Fettsäuren auf den Lipidstoffwechsel

Zusammenfassung

Immer wieder hört man, dass Omega-3-Fettsäuren die Blutfette senken. Doch was ist gesichert? Werden nur die Triglyzeride gesenkt oder auch das Cholesterin und hier besonders das als schädlich angesehene LDL? Haben alle Omega-3-Fettsäuren diese Effekte oder gibt es Unterschiede zwischen den einzelnen Omega-3-Fettsäuren? In diesem Artikel soll die wissenschaftliche Datenlage hierzu gesichtet werden.

Abstract

We always hear that omega-3 fatty acids lower blood lipids. But what is known fur sure? Are only the triglycerides lowered or is cholesterol also lowered, especially LDL, which is considered harmful? Do all omega-3 fatty acids have these effects or are there differences between individual omega-3 fatty acids? The purpose of this article is to review the scientific data on this.

Schlüsselwörter

Omega-3-Fettsäuren - ALA - EPA/DHA - Lipide - Triglyzeride - Cholesterin - HDL - LDL - sdLDL

Key words

Omega-3 fatty acids - ALA - EPA/DHA - lipids - triglycerides - cholesterol - HDL - LDL - sdLDL

• Literatur

• 1 Backes J, Anzalone D, Hilleman D. et al. The clinical relevance of omega-3 fatty acids in the management of hypertriglyceridemia. Lipids Health Dis 2016; 15 (01) 118
• 2 Weintraub HS. Overview of prescription omega-3 fatty acid products for hypertriglyceridemia. Postgrad Med 2014; 126 (07) 7-18
• 3 Choi HD, Chae SM. Comparison of efficacy and safety of combination therapy with statins and omega-3 fatty acids versus statin monotherapy in patients with dyslipidemia: A systematic review and meta-analysis. Medicine (Baltimore) 2018; 97 (50) e13593
• 4 Natto ZS, Yaghmoor W, Alshaeri HK. et al. Omega-3 fatty acids effects on inflammatory biomarkers and lipid profiles among diabetic and cardiovascular disease patients: A systematic review and meta-analysis. Sci Rep 2019; 9 (01) 18867
• 5 Marston NA, Giugliano RP, Im KA. et al. Association between triglyceride lowering and reduction of cardiovascular risk across multiple lipid-lowering therapeutic classes: A systematic review and meta-regression. Circulation 2019; 140 (16) 1308-1317
• 6 Goh YK, Jumpsen JA, Ryan EA. et al. Effect of omega-3 fatty acid on plasma lipids, cholesterol and lipoprotein fatty acid content in NIDDM patients. Diabetologia 1997; 40 (01) 45-52
• 7 Wilkinson P, Leach C, Ah-Sing EE. Influence of alpha-linolenic acid and fish-oil on markers of cardiovascular risk in subjects with an atherogenic lipoprotein phenotype. Atherosclerosis 2005; 181 (01) 115-124
• 8 Talebi S, Bagherniya M, Atkin SL. et al. The beneficial effects of nutraceuticals and natural products on small dense LDL levels, LDL particle number and LDL particle size: A clinical review. Lipids Health Dis 2020; 19 (01) 66
• 9 Elizabeth C, Leigh-Firbank EC, Minihane AM. et al. Eicosapentaenoic acid and docosahexaenoic acid from fish oils: Differential associations with lipid responses. Br J Nutr 2002; 87 (05) 435-445
• 10 Mahmoud Ebrahim M, Ghayour-Mobarhan M, Rezaiean S. et al. Omega-3 fatty acid supplements improve the cardiovascular risk profile of subjects with metabolic syndrome, including markers of inflammation and auto-immunity. Acta Cardiol 2009; 64 (03) 321-327
• 11 Green P, Fuchs J, Schoenfeld N. et al. Effects of fish-oil ingestion on cardiovascular risk factors in hyperlipidemic subjects in Israel: A randomized, double-blind crossover study. Am J Clin Nutr 1990; 52 (06) 1118-1124
• 12 Brown AJ, Roberts DC, Pritchard JE. et al. A mixed Australian fish diet and fish-oil supplementation: Impact on the plasma lipid profile of healthy men. Am J Clin Nutr 1990; 52 (05) 825-833
• 13 Nilsen DW, Albrektsen G, Landmark K. et al. Effects of a high-dose concentrate of n-3 fatty acids or corn oil introduced early after an acute myocardial infarction on serum triacylglycerol and HDL cholesterol. Am J Clin Nut 2001; 74 (01) 50-56
• 14 Kana Ide K, Masaya Koshizaka M, Tokuyama H. et al. N-3 polyunsaturated fatty acids improve lipoprotein particle size and concentration in Japanese patients with type 2 diabetes and hypertriglyceridemia: A pilot study. Lipids Health Dis 2018; 17 (01) 51