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Planta Med 2022; 88(14): 1267-1274
DOI: 10.1055/a-1665-3100
DOI: 10.1055/a-1665-3100
Biological and Pharmacological Activity
Reviews
Cannabinoids as New Drug Candidates for the Treatment of Glaucoma
Erin Jordan‡
1
Technical Biochemistry, TU Dortmund University, Dortmund, Germany
,
1
Technical Biochemistry, TU Dortmund University, Dortmund, Germany
2
MINDbioscience GmbH, Dortmund, Germany
,
Alexander Piechot
2
MINDbioscience GmbH, Dortmund, Germany
,
1
Technical Biochemistry, TU Dortmund University, Dortmund, Germany
› Author Affiliations
Abstract
Glaucoma is a blinding eye disease that affects about 70 million patients globally today. The cannabinoid receptors and the endocannabinoid system have found attention for new drug concepts. This review will analyze the potential of cannabinoids, primarily tetrahydrocannabinol, THCVS, and cannabinol, as drug candidates and the role of CB1/CB2 receptors with regard to the pathophysiology of glaucoma. The mode of action of cannabinoids as innovative drug candidates and recent formulations for topical delivery will be discussed. Cannabinoid receptors with associated TRPV channels will be evaluated for their potential as drug targets. Especially the role of the endocannabinoid system (fatty acid amide hydrolase, monoacylglycerol lipase) impacting the prostaglandin network (cyclooxygenase, PGE, PGF) and neuroprotection by inhibition of nitric oxide radical formation is in the focus of this review. Delivery systems, including recent clinical trials, will be analyzed to evaluate the potential for innovative future ophthalmological drugs.
Key words
tetrahydrocannabinol - cannabidiol - cannabinol - intraocular pressure - glaucoma - endocannabinoid system - COX-2 - MAGLPublication History
Received: 05 June 2021
Accepted after revision: 07 October 2021
Article published online:
17 March 2022
© 2022. Thieme. All rights reserved.
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