Synthesis 2022; 54(05): 1347-1352
Synthesis of Bis(indolyl)methanes through an Alkylation Reaction of Indoles with Sodium Alkoxides
Xue Chen
,
Yunkui Liu
,
Hongwei Jin
,
We thank the National Natural Science Foundation of China (Nos. 22001231 and 21772176) and the Natural Science Foundation of Zhejiang Province (Nos. LQ20B020012 and LY20B020013) for financial support.
Abstract
We describe an alkylation reaction of indoles with sodium alkoxides for the synthesis of bis(indolyl)methanes. 1-Tetralone proved to be an efficient hydrogen acceptor, thus avoiding the use of precious transition metals such as Ru and Ir. This reaction features transition-metal-free conditions, uses readily available starting materials, and can be conducted on a gram scale.
Key words
alkylation -
hydrogen transfer -
indole -
alcohol -
bis(indolyl)methane -
1-tetralone
Supporting Information
Supporting information for this article is available online at https://doi.org/10.1055/a-1668-9910.
Supporting Information
Publication History
Received: 14 September 2021
© 2021. Thieme. All rights reserved
Georg Thieme Verlag KG
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