Moderne Diagnosestellung der Amyotrophen Lateralsklerose – ein Update der Diagnosekriterien

Die Diagnose der Amyotrophen Lateralsklerose ist weiterhin eine Herausforderung. Sowohl die revidierten El-Escorial-Kriterien als auch die Awaji-Kriterien werden zum Teil in der klinischen Praxis genutzt, sind jedoch komplex und wenig sensitiv. Die neu vorgeschlagenen Gold-Coast-Kriterien stellen eine Erleichterung im klinischen Alltag dar. Eine Veranschaulichung der Diagnosefindung nach den verschiedenen Kriterien findet sich in dem Fallbeispiel.

The diagnosis of amyotrophic lateral sclerosis (ALS) is still challenging for clinicians. In the absence of a reliable biomarker, the clinical and electromyographic examination is of major importance to diagnose ALS. Mainly developed for clinical trials, the well-established revised El-Escorial criteria and Awaji criteria are sometimes also used in clinical routine. However, both diagnostic criteria are complex and disconcerting especially for patients because of various categories like “possible ALS” and “probable ALS”. Additionally, a definite diagnosis can only be made late in the course of the disease, or even sometimes it is not possible to fulfill the diagnostic criteria. The newly proposed Gold Coast criteria are a simplified synopsis of the previous diagnostic criteria. The combination of progressive symptoms, clinical or electromyographic evidence of lower and upper motor neuron dysfunction or progressive lower motor neuron dysfunction, and the exclusion of other diseases lead to the diagnosis of ALS.

Schlüsselwörter

Amyotrophe Lateralsklerose - El-Escorial-Kriterien - Awaji-Kriterien - Gold-Coast-Kriterien

Key word

amyotrophic lateral sclerosis - El Escorial criteria - Awaji criteria - Gold Coast Criteria

Publication History

Article published online:
02 March 2022

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