Die Bedeutung von Lactoferrin im Sport – am Beispiel von Amateurfußballern

Zusammenfassung

Fußball, aber potenziell auch jede andere Sportart, kann eine körperbetonte und intensive Belastung für den menschlichen Organismus darstellen. Neben sichtbaren Verletzungen wie Zerrungen, Bänderrissen oder Knochenbrüchen gibt es weitere Symptome, die latent vorhanden, aber nicht genau zuzuordnen sind. Chronische Müdigkeit, Abgeschlagenheit, rezidivierende Infektanfälligkeit, Konzentrationsstörungen und längere Regenerationszeiten werden in der Regel nicht mit der sportlichen Tätigkeit in Verbindung gebracht.

Diese Symptome können auf eine Unterversorgung mit Vitalstoffen, insbesondere des Spurenelements Eisen, hinweisen.

Abstract

Soccer, but potentially any other sport, can mean physical and intense stress for the human organism. In addition to visible injuries such as strains, torn ligaments or broken bones, there are other symptoms that are latently present but cannot be precisely attributed. Chronic fatigue, exhaustion, recurrent susceptibility to infections, concentration problems, and longer regeneration times are not usually associated with sporting activity.

These symptoms may indicate an undersupply of vital substances, especially of the trace element iron.

Schlüsselwörter

Lactoferrin - Eisen - Eisenmangel - Sport

Key words

Lactoferrin - iron - iron deficiency - sport

Publication History

Article published online:
23 February 2022

• Literatur

• 1 Murray-Kolb LE, Beard JL. Iron treatment normalizes cognitive functioning in young women. Am J Clin Nutr 2007; 85: 778-787
• 2 Cherayil BJ. Iron and Immunity: Immunological Consequences of Iron Deficiency and Overload. Arch Immunol Ther Exp (Warsz) 2010; 58: 407-415
• 3 Schaible UE, Kaufmann SHE. Iron and microbial infection. Nat Rev Microbiol 2004; 2: 946-953
• 4 Saller R, Römer-Lüthi C, Brignoli R. et al. Eisen – ein zweischneidiges Schwert? Systematischer Review zur klinischen Bedeutung eines essenziellen Spurenelements. Swiss J Integr Med 2007; 19: 96-103
• 5 Vaulont S. Of mice and men: the iron age. J Clin Invest 2005; 115: 2079-2082
• 6 Doherty CP. Host-Pathogen Interactions: The Role of Iron. J Nutr 2007; 137: 1341-1344
• 7 Hood MI, Skaar EP. Nutritional immunity: transition metals at the pathogen-host interface. Nat Rev Microbiol 2012; 10: 525-537
• 8 Cassat JE, Skaar EP. Iron in infection and immunity. Cell Host Microbe 2013; 13: 509-519
• 9 Andrews NC, Schmidt PJ. Iron Homeostasis. Annu Rev Physiol 2007; 69: 69-85
• 10 Lee P, Peng H, Gelbart T. et al. E. Regulation of hepcidin transcription by interleukin-1 and interleukin-6. Proc Natl Acad Sci 2005; 102: 1906-1910
• 11 Gulec S, Anderson GJ, Collins JF. Mechanistic and regulatory aspects of intestinal iron absorption. Am J Physiol Gastrointest Liver Physiol 2014; 307: G397-G409
• 12 Wrighting DM, Andrews NC. Interleukin-6 induces hepcidin expression through STAT3. Blood 2006; 108: 3204-3209
• 13 Shephard RJ. Cytokine responses to physical activity, with particular reference to IL-6: sources, actions, and clinical implications. Crit Rev Immunol 2002; 22: 165-182
• 14 Helge JW. et al. The effect of graded exercise on IL-6 release and glucose uptake in human skeletal muscle. J Physiol 2003; 546: 299-305
• 15 Fasano A. Zonulin and its regulation of intestinal barrier function: the biological door to inflammation, autoimmunity, and cancer. Physiol Rev 2011; 91: 151-175
• 16 Dokladny K, Moseley PL, Ma TY. Physiologically relevant increase in temperature causes an increase in intestinal epithelial tight junction permeability. Am J Physiol Gastrointest Liver Physiol 2006; 290: G204-G212
• 17 Perdijk O, van Neerven R, van den Brink E. et al. Bovine Lactoferrin Modulates Dendritic Cell Differentiation and Function. Nutrients 2018; 10: 848
• 18 Sawatzki G. Lactoferrin in Infant Formulas. Lactoferrin 1997; 28: 89-397
• 19 Kanwar JR. et al. Multifunctional Iron Bound Lactoferrin and Nanomedicinal Approaches to Enhance Its Bioactive Functions. Molecules 2015; 20: 9703-9731
• 20 Lepanto MS. et al. Efficacy of Lactoferrin Oral Administration in the Treatment of Anemia and Anemia of Inflammation in Pregnant and Non-pregnant Women: An Interventional Study. Front Immunol 2018; 9: 2123
• 21 Paesano R.. et al. Lactoferrin efficacy versus ferrous sulfate in curing iron disorders in pregnant and non-pregnant women. Int J Immunopathol Pharmacol 2010; 23: 577-587
• 22 Thomas C, Kobold U, Thomas L. Serum hepcidin-25 in comparison to biochemical markers and hematological indices for the differentiation of iron-restricted erythropoiesis. Clin Chem Lab Med 2011; 49
• 23 Minihane AM. et al. Low-grade inflammation, diet composition and health: current research evidence and its translation. Br J Nutr 2015; 114: 999-1012
• 24 Straub RH. Insulin resistance, selfish brain, and selfish immune system: an evolutionarily positively selected program used in chronic inflammatory diseases. Arthritis Res Ther 2014; 16: 4
• 25 Pammi M, Suresh G. Enteral lactoferrin supplementation for prevention of sepsis and necrotizing enterocolitis in preterm infants. Cochrane Database Syst Rev 2017; 6: CD007137
• 26 Castelletto V. et al. Structurally plastic peptide capsules for synthetic antimicrobial viruses. Chem Sci 2016; 7: 1707-1711
• 27 Müller A. Hat die tägliche Gabe von 800 mg Lactoferrin CLN™ bei semiprofessionellen Fußballern unter der normalen saisonalen Belastung einen Einfluss auf deren Eisenhaushalt? [Masterarbeit]. Idstein: Hochschule Fresenius; 2020. (nicht veröffentlicht)