Abstract
Objective To evaluate the serum vasostatin-1 levels in preeclamptic and
non-preeclamptic pregnant women.
Materials and methods Thirty consecutive women with mild preeclampsia and
sixty consecutive women with severe preeclampsia were compared with ninety
gestational age-matched (±1 week) non-preeclamptic pregnant women with
an appropriate-for-gestational-age (AGA) fetus.
Results Mean serum vasostatin-1 was significantly higher in women with
preeclampsia than gestational age-matched controls. Mean serum vasostatin-1 was
significantly higher in the mild preeclampsia group compared to its gestational
age-matched control group, and in the severe preeclampsia group compared to its
gestational age-matched control group. There was no significant difference in
mean serum vasostatin-1 levels between the mild and severe preeclampsia groups,
and in severe early- and severe late-onset preeclampsia groups. Serum
vasostatin-1 had positive correlations with systolic and diastolic blood
pressure.
Conclusion Serum vasostatin-1 was significantly higher in women with
preeclampsia compared to those of the gestational age-matched controls. There
was no significant difference in mean serum vasostatin-1 levels between the mild
and severe preeclampsia groups and severe early- and severe late-onset
preeclampsia groups.
Key words
Angiogenesis - blood pressure - chromogranin A - peptide fragment
