Synthesis, Table of Contents Synthesis 2022; 54(11): 2585-2594DOI: 10.1055/a-1748-6564 feature Addition/Substitution Approach of TsNHCH2SiMe2CH2Cl with Isocyanates or Isothiocyanates To Construct 1,3,5-Diazasilinan-2-ones or 1,3,5-Thiazasilinan-2-imines Yi Li‡ , Tianbao Hu‡ , Lu Gao∗ , Zhenlei Song ∗ Recommend Article Abstract Buy Article All articles of this category Abstract TsNHCH2SiMe2CH2Cl has been exploited as a 1,4-dipole synthon for the synthesis of 1,3,5-diazasilinan-2-ones by a sequential N-addition/N-substitution process with isocyanates, or for the synthesis of 1,3,5-thiazasilinan-2-imines with isothiocyanates by a sequential N-addition/S-substitution process. Key words Key wordssilaazacycles - ‘carbon-silicon’ switching - 1,3,5-diazasilinan-2-one - 1,3,5-thiazasilinan-2-imine - cyclization Full Text References References 1a Serafini M, Cargnin S, Massarotti A, Tron GC, Pirali T, Genazzani AA. J. Med. 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