Iridium-Catalyzed Formal [4+1] Annulation of Benzamides and Cyclopropanols to Afford Isoindolin-1-one Derivatives via C–H Activation

Abstract

An iridium-catalyzed reaction protocol has been developed to achieve the oxidative C–H/N–H annulation of benzamides with cyclopropanols as C1 synthon. Structurally diverse isoindolin-1-ones were furnished via sequential C–H/C–C cleavage and C–C/C–N bond formation.

Key words

C–H activation - benzamides - cyclopropanols - C–N bond formation - isoindolin-1-ones

Publikationsverlauf

Eingereicht: 27. Januar 2022

Angenommen nach Revision: 23. Februar 2022

Accepted Manuscript online:
23. Februar 2022

Artikel online veröffentlicht:
05. April 2022

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