Rhodium(I)-Catalyzed Regioselective C–H Alkenylation of 2,2′-Bipyridine Derivatives with Alkynes

Abstract

In this work, a Rh(I)-catalyzed C3-alkenylation of 2,2′-bipyri­dine-6-carboxamide with terminal and internal alkynes was developed, providing an efficient access to a broad range of alkenylated 2,2′-bipyridine derivatives with exclusive regioselectivity and stereoselectivity. Deuterium labeling experiments indicate that an irreversible rollover C–H activation process is involved in this reaction.

Key words

rhodium - C–H activation - rollover cyclometalation - alkenylation - 2,2′-bipyridine

Publication History

Received: 29 December 2021

Accepted after revision: 07 March 2022

Accepted Manuscript online:
07 March 2022

Article published online:
25 April 2022

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