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TumorDiagnostik & Therapie 2022; 43(03): 187-196
DOI: 10.1055/a-1794-8370
DOI: 10.1055/a-1794-8370
Thieme Onkologie aktuell
Die Expression des prostataspezifischen Membranantigens (PSMA) beim Mammakarzinom
Expression of Prostate Specific Membrane Antigen (PSMA) in Breast Cancer
Zusammenfassung
Hintergrund Das prostataspezifische Membranantigen (PSMA) ist für Mammakarzinompatientinnen ein vielversprechendes Protein. Es wurde bisher nicht nur beim Prostatakarzinom nachgewiesen, sondern wird auch von den Tumor- sowie Endothelzellen der Tumorgefäße des Mammakarzinoms exprimiert. Das PSMA hat eine Rolle bei der Tumorprogression und Neubildung von Gefäßen. Deshalb wurden bereits viele PSMA-gerichtete diagnostische und therapeutische Verfahren entwickelt.
Methode Diese Arbeit ist eine allgemeine und gegliederte Übersicht über das PSMA und dessen onkogenetisches Potenzial, mit dem Fokus auf dessen Rolle beim Mammakarzinom. Für dieses narrative Review wurde eine selektive Literaturrecherche via PubMed und der Bibliothek des Universitätsklinikums Freiburg angefertigt. Hierbei wurden folgende Schlüsselwörter verwendet: „PSMA“, „PSMA and breast cancer“, „PSMA PET/CT“, „PSMA tumor progression“. Relevante Artikel wurden explizit durchgelesen, bearbeitet und zusammengefasst.
Schlussfolgerung Das PSMA könnte, insbesondere beim triple-negativen Mammakarzinom, eine neue diagnostische und therapeutische Alternative darstellen. Es scheint ein möglicher prädiktiver und prognostischer Marker zu sein.
Abstract
Background Prostate specific membrane antigen (PSMA) is a promising protein for breast cancer patients. It has not only been detected in prostate cancer but is also expressed by tumor cells and the endothelial cells of tumor vessels in breast cancer patients. PSMA plays a role in tumor progression and tumor angiogenesis. For this reason, a number of diagnostic and therapeutic methods to target PSMA have been developed.
Method This paper provides a general structured overview of PSMA and its oncogenic potential, with a special focus on its role in breast cancer. This narrative review is based on a selective literature search carried out in PubMed and the library of Freiburg University Clinical Center. The following key words were used for the search: “PSMA”, “PSMA and breast cancer”, “PSMA PET/CT”, “PSMA tumor progression”. Relevant articles were explicitly read through, processed, and summarized.
Conclusion PSMA could be a new diagnostic and therapeutic alternative, particularly for triple-negative breast cancer. It appears to be a potential predictive and prognostic marker.
Publication History
Received: 15 April 2021
Accepted after revision: 06 September 2021
Article published online:
04 April 2022
© 2022. The Author(s). This article was originally published by Thieme in Geburtsh Frauenheilk 2022; 82: 50–58 as an open access article under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).
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