Die Bedeutung von Vitamin E als Antioxidans

Vitamin E ist bekannt als das wichtigste fettlösliche Antioxidans im Menschen. In Lipoproteinen, Zellmembranen und im Fettgewebe nimmt es eine führende Rolle bei der Abwehr von oxidativem Stress ein. Dabei wirkt es als „chain-breaking“ Antioxidans und hemmt spezifisch Kettenreaktionen der Lipid-Peroxidation. Darüber hinaus redox-reguliert Vitamin E Signaltransduktion, Genexpression, Enzymaktivitäten und Metabolismus.

Publikationsverlauf

Artikel online veröffentlicht:
07. Juni 2022

• Literatur

• 1 Blaner WS, Shmarakov IO, Traber MG.. Vitamin A and vitamin E: will the real antioxidant please stand up?. Annu Rev Nutr 2021; 41: 105-131
• 2 Brigelius-Flohe R.. Vitamin E research: past, now and future. Free Radic Biol Med 2021; 177: 381-390
• 3 Azzi A.. Reflections on a century of vitamin E research: Looking at the past with an eye on the future. Free Radic Biol Med 2021; 175: 155-160
• 4 Miyazawa T, Burdeos GC, Itaya M. et al. Vitamin E: regulatory redox interactions. IUBMB Life 2019; 71: 430-441
• 5 Zingg JM.. Vitamin E: Regulatory role on signal transduction. IUBMB Life 2019; 71: 456-478
• 6 Mattill HA, Conklin RA.. The nutritive properties of milk, with special reference to reproduction in the albino rat. J Biol Chem 1920; 44: 137-158
• 7 Evans HM, Bishop KS.. Existence of a hitherto unknown dietary factor essential for reproduction. J Am Med Assoc 1923; 81: 889-892
• 8 Evans HM, Bishop KS.. The production of sterility with nutritional regimes adequate for growth and its cure with other foodstuffs. J Metab Res 1923; 3: 234-316
• 9 Mattill HA, Carman JS, Clayton MM.. The nutritive properties of milk. III. The effectiveness of the X substance in preventing sterility in rats on milk rations high in fat. J Biol Chem 1924; 61: 729-740
• 10 Mattill HA.. The oxidative destruction of vitamins A and E and the protective action of certain vegetable oils. J Am Med Assoc 1927; 89: 1505-1508
• 11 Cummings MJ, Mattill HA.. The auto-oxidation of fats with reference to their destructive effect on vitamin E. J Nutr 1931; 3: 421-432
• 12 Wolf G.. The discovery of the antioxidant function of vitamin E: the contribution of Henry A. Mattill. J Nutr 2005; 135: 363-366
• 13 Tappel AL, Zalkin H.. Inhibition of lipide peroxidation in mitochondria by vitamin E. Arch Biochem Biophys 1959; 80: 333-336
• 14 Tappel AL, Zalkin H.. Inhibition of lipid peroxidation in microsomes by vitamin E. Nature 1960; 4705: 35
• 15 Rose CS, György P.. Specificity of hemolytic reaction in vitamin E-deficient erythrocytes. Amer J Physiol 1952; 168: 414-420
• 16 Leth T, Sondergaard H.. Biological activity of vitamin E compounds and natural materials by the resorption-gestation test, and chemical determination of the vitamin E activity in foods and feeds. J Nutr 1977; 107: 2236-2243
• 17 Aggarwal BB, Sundaram C, Prasad S, Kannappan R.. Tocotrienols, the vitamin E of the 21st century: its potential against cancer and other chronic diseases. Biochem Pharmacol 2010; 80: 1613-1631
• 18 Niki E, Noguchi N.. Antioxidant action of vitamin E in vivo as assessed from its reaction products with multiple biological oxidants. Free Rad Res 2021; 55: 352-363
• 19 Burton GW, Ingold KU.. Autoxidation of biological molecules. 1. The antioxidant activity of vitamin E and related chain-breaking phenolic antioxidants in vitro 1. J Amer Chem Soc 1981; 103: 6472-6477
• 20 Burton GW, Joyce A, Ingold KU.. First proof that vitamin E is major lipid-soluble, chain-breaking antioxidant in human blood plasma. Lancet 1982; 2: 327
• 21 Ingold KU, Webb AC, Witter D. et al. Vitamin E remains the major lipid-soluble, chain-breaking antioxidant in human plasma even in individuals suffering severe vitamin E deficiency. Arch Biochem Biophys 1987; 259: 224-225
• 22 Kamal-Eldin A, Appelqvist LA.. The chemistry and antioxidant properties of tocopherols and tocotrienols. Lipids 1996; 31: 671-701
• 23 Zanetti R, Catalá A.. Changes in n-6 and n-3 polyunsaturated fatty acids during lipid-peroxidation of mitochondria obtained from rat liver and several brain regions: effect of α-tocopherol. Prostaglandins. Leukot Essent Fatty Acids 2000; 62: 379-385
• 24 Packer L.. Interactions among antioxidants in health and disease: vitamin E and its redox cycle. Proc Soc Exp Biol Med 1992; 200: 271-276
• 25 Burton GW, Ingold KU.. Vitamin E as an in vitro and in vivo antioxidant. Ann N Y Acad Sci 1989; 570: 7-22
• 26 Packer L, Smith JR.. Extension of the lifespan of cultured normal human diploid cells by vitamin E: a reevaluation. Proc Natl Acad Sci USA 1977; 74: 1640-1641
• 27 Hiramatsu M, Velasco RD, Wilson DS, Packer L.. Ubiquinone protects against loss of tocopherol in rat liver microsomes and mitochondrial membranes. Res Commun Chem Pathol Pharmacol 1991; 72: 231-241
• 28 Kitazawa M, Podda M, Thiele J. et al. Interactions between vitamin E homologues and ascorbate free radicals in murine skin homogenates irradiated with ultraviolet light. Photochem Photobiol 1997; 65: 355-365
• 29 Thiele JJ, Schroeter C, Hsieh SN. et al. The antioxidant network of the stratum corneum. Curr Probl Dermatol 2001; 29: 26-42
• 30 Packer L, Obermüller-Jević UC.. Vitamin E: An introduction. In: Packer L, Traber MG, Kramer K et al., eds. The antioxidant vitamins C and E.. Champaign, IL: AOCS Press; 2002: 133-151
• 31 Kim HK, Han SN.. Vitamin E: regulatory role on gene and protein expression and metabolomics profiles. IUBMB Life 2019; 71: 442-455
• 32 Rimbach G, Moehring J, Huebbe P, Lodge JK.. Gene-regulatory activity of α-tocopherol. Molecules 2010; 15: 1746-1761
• 33 Cadenas S, Rojas C, Mendez J. et al. Vitamin E decreases urine lipid peroxidation products in young healthy human volunteers under normal conditions. Pharmacol Toxicol 1996; 79: 247-253
• 34 Sun Y, Ma A, Li Y. et al. Vitamin E supplementation protects erythrocyte membranes from oxidative stress in healthy Chinese middle-aged and elderly people. Nutr Res 2012; 32: 328-334
• 35 Goon JA, Azman NHEN, Ghani SMA. et al. Comparing palm oil tocotrienol rich fraction with α-tocopherol supplementation on oxidative stress in healthy older adults. Clin Nutr ESPEN 2017; 21: 1-12
• 36 Hodis HN, Mack WJ, LaBree L. et al. VEAPS Research Group Alpha-tocopherol supplementation in healthy individuals reduces low-density lipoprotein oxidation but not atherosclerosis: the Vitamin E Atherosclerosis Prevention Study (VEAPS). Circulation 2002; 106: 1453-1439
• 37 Chao WH, Askew EW, Roberts DE. et al. Oxidative stress in humans during work at moderate altitude. J Nutr 1999; 129: 2009-2012
• 38 Block G, Jensen CD, Morrow JD. et al. The effect of vitamins C and E on biomarkers of oxidative stress depends on baseline level. Free Radic Biol Med 2008; 45: 377-384
• 39 Gaeini AA, Rahnama N, Hamedinia MR.. Effects of vitamin E supplementation on oxidative stress at rest and after exercise to exhaustion in athletic students. J Sports Med Phys Fitness 2006; 46: 458-461
• 40 Silva LA, Pinho CA, Silveira PCL. et al. Vitamin E supplementation decreases muscular and oxidative damage but not inflammatory response induced by eccentric contraction. J Physiol Sci 2010; 60: 51-57
• 41 Sacheck JM, Milbury PE, Cannon JG. et al. Effect of vitamin E and eccentric exercise on selected biomarkers of oxidative stress in young and elderly men. Free Radic Biol Med 2003; 34: 1575-1588
• 42 Avery NG, Kaiser JL, Sharman MJ. et al. Effects of vitamin E supplementation on recovery from repeated bouts of resistance exercise. J Strength Cond Res 2003; 17: 801-809
• 43 Van Tits LJ, de Waart F, Hak-Lemmers HL. et al. Effects of alpha-tocopherol on superoxide production and plasma intercellular adhesion molecule-1 and antibodies to oxidized LDL in chronic smokers. Free Radic Biol Med 2001; 30: 1122-1129
• 44 Neunteufl T, Priglinger U, Heher S. et al. Effects of vitamin E on chronic and acute endothelial dysfunction in smokers. J Am Coll Cardiol 2000; 35: 277-283
• 45 De Oliveira DCX, Rosa FT, Simoes-Ambrosio L. et al. Antioxidant vitamin supplementation prevents oxidative stress but does not enhance performance in young football athletes. Nutrition 2019; 63-64: 29-35
• 46 Sureda A, Ferrer MD, Mestre A. et al. Prevention of neutrophil protein oxidation with vitamins C and E diet supplementation without affecting the adaptive response to exercise. Int J Sport Nutr Exerc Metab 2013; 23: 31-39
• 47 Zal F, Mostafavi-Pour Z, Amini F, Heidari A. Effect of vitamin E and C supplements on lipid peroxidation and GSH-dependent antioxidant enzyme status in the blood of women consuming oral contraceptives. Contraception 2012; 81: 62-66
• 48 Simar D, Malatesta D, Delage M, Caillaud C. Effect of an 8-weeks aerobic training program in elderly on oxidative stress and HSP72 expression in leukocytes during antioxidant supplementation. J Nutr Health Aging 2012; 16: 155-161
• 49 Retana-Ugalde R, Casanueva E, Altamirano-Lozano M. High dosage of ascorbic acid and alpha-tocopherol is not useful for diminishing oxidative stress and DNA damage in healthy elderly adults. Ann Nutr Metab 2008; 52: 167-173
• 50 Goldfarb A, McKenzie M, Bloomer RJ. Gender comparisons of exercise-induced oxidative stress: influence of antioxidant supplementation. Appl Physiol Nutr Metab 2007; 32: 1124-1131
• 51 Lara-Padilla E, Kormanovski A, Grave PA. et al. Increased antioxidant capacity in healthy volunteers taking a mixture of oral antioxidants versus vitamin C or E supplementation. Adv Ther 2007; 24: 50-59
• 52 Bloomer RJ, Goldfarb AH, McKEnzie MJ. Oxidative stress response to aerobic exercise: comparison of antioxidant supplements. Med Sci Sports Exerc 2006; 38: 1098-1105
• 53 Porkkala-Sarataho E, Salonen JT, Nyssönen K. et al. Long-term effects of vitamin E, vitamin C, and combined supplementation on urinary 7-hydro-8-oxo-2'-deoxyguanosine, serum cholesterol oxidation products, and oxidation resistance of lipids in nondepleted men. Arterioscler Thromb Vasc Biol 2000; 20: 2087-2093
• 54 Meraji S, Ziouzenkova O, Resch U. et al. Enhanced plasma level of lipid peroxidation in Iranians could be improved by antioxidants supplementation. Eur J Clin Nutr 1997; 51: 318-325
• 55 Rokitzki L, Logemann E, Sagredos AN. et al. Lipid peroxidation and antioxidative vitamins under extreme endurance stress. Acta Physiol Scand 1994; 151: 149-158
• 56 Kanter MM, Nolte LA, Holloszy JO. Effects of an antioxidant vitamin mixture on lipid peroxidation at rest and postexercise. J Appl Physiol (1985) 1993; 74: 965-969
• 57 Wang Q, Sun Y, Ma A. et al. Effects of vitamin E on plasma lipid status and oxidative stress in Chinese women with metabolic syndrome. Int J Vitam Nutr Res 2010; 80: 178-187
• 58 Devaraj S, Leonard S, Traber MG, Jialal I. Gamma-tocopherol supplementation alone and in combination with alpha-tocopherol alters biomarkers of oxidative stress and inflammation in subjects with metabolic syndrome. Free Radic Biol Med 2008; 44: 1203-1208
• 59 Devaraj S, Tang R, Adams-Huet B. et al. Effect of high-dose alpha-tocopherol supplementation on biomarkers of oxidative stress and inflammation and carotid atherosclerosis in patients with coronary artery disease. Am J Clin Nutr 2007; 86: 1392-1398
• 60 Hodis HN, Mack WJ, LaBree L. et al. Alpha-tocopherol supplementation in healthy individuals reduces low-density lipoprotein oxidation but not atherosclerosis: the Vitamin E Atherosclerosis Prevention Study (VEAPS). Circulation 2002; 106: 1453-1459
• 61 Motoyama T, Kawano H, Kugiyama K. et al. Vitamin E administration improves impairment of endothelium-dependent vasodilation in patients with coronary spastic angina. J Am Coll Cardiol 1998; 32: 1672-1679
• 62 Adema AY, van Ittersum FJ, Hoenderop JG. et al. Reduction of oxidative stress in chronic kidney disease does not increase circulating α-Klotho concentrations. PLoS One 2016; 11: e0144121
• 63 Khatami PG, Soleimani A, Sharifi N. et al. The effects of high-dose vitamin E supplementation on biomarkers of kidney injury, inflammation, and oxidative stress in patients with diabetic nephropathy: A randomized, double-blind, placebo-controlled trial. J Clin Lipidol 2016; 10: 922-929
• 64 Uzum A, Toprak O, Gumustas MK. et al. Effect of vitamin E therapy on oxidative stress and erythrocyte osmotic fragility in patients on peritoneal dialysis and hemodialysis. J Nephrol 2006; 19: 739-745
• 65 Baldi S, Innocenti M, Frascerra S. et al. Effects of hemodialysis and vitamin E supplementation on low-density lipoprotein oxidizability in end-stage renal failure. J Nephrol 2013; 26: 549-555
• 66 Mafra D, Santos FR, Lobo JC. et al. Alpha-tocopherol supplementation decreases electronegative low-density lipoprotein concentration [LDL(-)] in haemodialysis patients. Nephrol Dial Transplant 2009; 24: 1587–1592
• 67 Arato E, Kürthy M, Sinay L. et al. Effect of vitamin E on reperfusion injuries during reconstructive vascular operations on lower limbs. Clin Hemorheol Microcirc 2010; 44: 125-136
• 68 Novelli GP, Adembri C, GAndini E. et al. Vitamin E protects human skeletal muscle from damage during surgical ischemia-reperfusion. Am J Surg 1997; 173: 206-209
• 69 Keith ME, Jeejeebhoy KN, Langer A. et al. A controlled clinical trial of vitamin E supplementation in patients with congestive heart failure. Am J Clin Nutr 2001; 73: 219-227
• 70 Daud ZAM, Tubie B, Sheyman M. et al. Vitamin E tocotrienol supplementation improves lipid profiles in chronic hemodialysis patients. Vasc Health Risk Manag 2013; 9: 747-761
• 71 Tappel AL, Zalkin H.. Inhibition of lipide peroxidation in mitochondria by vitamin E. Archives Biochem Biophys 1959; 80: 333-336
• 72 Horwitt MK, Harvey CC, Duncan GD, Wilson WC.. Effects of limited tocopherol intake in man with relationships to erythrocyte hemolysis and lipid oxidations. Am J Clin Nutr 1956; 4: 408-419
• 73 Horwitt MK.. Vitamin E and lipid metabolism in man. Am J Clin Nutr 1960; 8: 451-461
• 74 Horwitt MK, Harvey CC, Dahm CH, Searcy MT.. Relationship between tocopherol and serum lipid levels for determination of nutritional adequacy. Ann N Y Acad Sci 1972; 203: 223-236
• 75 Horwitt MK.. Status of human requirements for vitamin E. Am J Clin Nutr 1974; 27: 1182-1193
• 76 Deutsche Gesellschaft für Ernährung (DGE), Österreichische Gesellschaft für Ernährung (ÖGE), Schweizerische Gesellschaft für Ernährung (SGE). Referenzwerte für die Nährstoffzufuhr. 2. Aufl., 7. aktualisierte Ausgabe.. Bonn: DGE; 2021
• 77 Institute of Medicine (US) Panel on Dietary Antioxidants and Related Compounds. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington (DC): National Academies Press (US); 2000: 67
• 78 EFSA Panel on Dietetic Products, Nutrition, and Allergies. Scientific Opinion on Dietary Reference Values for vitamin E as α-tocopherol. EFSA Journal 2015; 13: 4149