The Mechanism of Hyperoxia-Induced Neonatal Renal Injury and the Possible Protective Effect of Resveratrol

Abstract

With recent advances in neonatal intensive care, preterm infants are surviving into adulthood. Nonetheless, epidemiological data on the health status of these preterm infants have begun to reveal a worrying theme; prematurity and the supplemental oxygen therapy these infants receive after birth appear to be risk factors for kidney disease in adulthood, affecting their quality of life. As the incidence of chronic kidney disease and the survival time of preterm infants both increase, the management of the hyperoxia-induced renal disease is becoming increasingly relevant to neonatologists. The mechanism of this increased risk is currently unknown, but prematurity itself and hyperoxia exposure after birth may predispose to disease by altering the normal trajectory of kidney maturation. This article reviews altered renal reactivity due to hyperoxia, the possible mechanisms of renal injury due to hyperoxia, and the role of resveratrol in renal injury.

Key Points

• Premature infants commonly receive supplementary oxygen.

• Hyperoxia can cause kidney damage via signal pathways.

• We should reduce the occurrence of late sequelae.

Keywords

resveratrol - hyperoxia - renal injury - CKD

Authors' Contributions

Y.S. wrote the manuscript. Y.Y. provides support in investigation and data collation. W.D. audited the manuscript. All authors contributed to the article and approved the submitted version.

Publication History

Received: 29 August 2021

Accepted: 17 March 2022

Accepted Manuscript online:
05 April 2022

Article published online:
04 July 2022

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