Potenziell unangemessene Medikamente (PIM) für ältere Patienten: Wie werden pflanzliche Arzneimittel beurteilt?

Zusammenfassung

Bestimmte Arzneistoffe und Arzneistoffklassen sind potenziell bei älteren Patienten unangemessen (PIM), insbesondere wegen ihres Nebenwirkungsspektrums. Sie sollten deswegen abgesetzt und gegebenenfalls ausgetauscht werden. Zur Unterstützung des oft komplexen Entscheidungsprozesses wurden in vielen Ländern seit 25 Jahren PIM-Listen entwickelt. In diesem Artikel werden für Deutschland bzw. den europäischen Raum zur Verfügung stehende PIM-Listen einschließlich ihres Entwicklungsprozesses und hinsichtlich enthaltener Aussagen zu Phytotherapie vorgestellt.

Abstract

Potentially Inappropriate Medications (PIM) for Geriatric Patients: How are Herbal Medicines Assessed?

Specific drugs and classes of drugs are potentially inadequate for geriatric patients (PIM), especially due to their spectrum of adverse effects. They therefore should be stopped and eventually be substituted. In the last 25 years, PIM lists have been developed in many countries in order to support this decision process that is often complex. In this article, PIM lists from Germany and Europe are presented including their development process with respect to the provided statements on phytotherapy.

Schlüsselwörter

Potenziell unangemessene Medikamente - PIM - ältere Patienten - Phytotherapie

Key words

potentially inappropriate medications - PIM - geriatric patients - phytotherapy

Publication History

Article published online:
08 September 2022

• Literatur

• 1 2019 American Geriatrics Society Beers Criteria®Update Expert Panel.. American Geriatrics Society 2019 Updated AGS Beers Criteria^® for potentially inappropriate medication use in older adults. J Am Geriatr Soc 2019; 67: 674-694
• 2 Beers MH. Explicit criteria for determining potentially inappropriate medication use by the elderly. An update. Arch Intern Med 1997; 157: 1531-1536
• 3 McLeod PJ. et al. Defining inappropriate practices in prescribing for elderly people: a national consensus panel. Can Med Assoc J 1997; 156: 385-391
• 4 Laroche ML, Charmes JP, Merle L. Potentially inappropriate medications in the elderly: a French consensus panel list. Eur J Clin Pharmacol 2007; 63: 725-731
• 5 Holt S, Schmiedl S, Thurmann PA. Potentially inappropriate medications in the elderly: the PRISCUS list. Dtsch Arztebl Int 2010; 107: 543-551
• 6 https://www.pharmazeutische-zeitung.de/was-gibt-es-neues-in-der-priscus-liste-129906/
• 7 https://www.priscus2-0.de/
• 8 Wehling M. Arzneimitteltherapie im Alter: Zu viel und zu wenig, was tun?. Ein neues Bewertungssystem: fit for the aged (FORTA). Dtsch Med Wochenschr 2008; 133: 2289-2291
• 9 https://www.umm.uni-heidelberg.de/index.php?eID=tx_nawsecuredl&u=0&g=0&t=1657096063&hash=0a455d7eabd4971503db5ac693ad070ddd094624&file=fileadmin/medma/Lehrstuehle/Wehling/FORTA_List_2021_with_comments_and_stats.pdf (Zugriff am 30.6.2022)
• 10 Renom-Guiteras A, Meyer G, Thürmann PA. The EU(7)-PIM list: a list of potentially inappropriate medications for older people consented by experts from seven European countries. Eur J Clin Pharmacol 2015; 71: 861-875
• 11 Novaes PH. et al. The «iatrogenic triad»: Polypharmacy, drug-drug interactions, and potentially inappropriate medications in older adults. Int J Clin Pharm 2017; 39: 818-825
• 12 Bories M. et al. Drug-drug interactions in elderly patients with potentially inappropriate medications in primary care, nursing home and hospital settings: A systematic review and a preliminary study. Pharmaceutics 2021; 13: 266
• 13 FDA in Vitro Drug Interaction Studies, Cytochrome P450 Enzyme and Transporter Mediated Drug Interactions –Guidance for industry; U.S. Department of Health and Human Services, Center for Drug Evaluation and Research: Silver Spring, MD, USA, 2020; Vol. 46
• 14 Kaufmann CP. et al. Inappropriate prescribing: a systematic overview of published assessment tools. Eur J Clin Pharmacol 2014; 70: 1-11
• 15 Campbell SM, Cantrill JA. Consensus methods in prescribing research. J Clin Pharm Ther 2001; 26: 5-14
• 16 Marriott J, Stehlik P. A critical analysis of the methods used to develop explicit clinical criteria for use in older people. Age Ageing 2012; 41: 441-450