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DOI: 10.1055/a-1878-8448
A Novel and Practical Synthesis of Tryptanthrin
The Key project of Anhui Provincial Department of Education, China (NO. KJ2020A672) and The Open Fund Project of Anhui Key Laboratory of Pharmaceutical Preparation Technology and Application (NO. 2021KFKT01 and 2021KFKT08).
Abstract
Tryptanthrin was synthesized through a two-step reaction of oxidation and condensation in a one-pot method, with isatin and sodium hypochlorite as starting materials. The influence of sodium hypochlorite, acetonitrile dosage, oxidation reaction temperature, and reaction time on the yield of the target product during the reaction was investigated. The following optimal reaction conditions were obtained: the ratio of n (isatin) to n (sodium hypochlorite) was 2:1, and the reaction time was 6–8 hours at room temperature. The structure of tryptanthrin was confirmed by matching the IR, NMR, and mass data with the literature report. The study shows that the chemical reaction route designed in this report is short, with high yield and purity of the target product. Its low production cost and simple operation method are expected to be applicable to industrial production.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-1878-8448.
- Supporting Information
Publication History
Received: 24 April 2022
Accepted after revision: 20 June 2022
Accepted Manuscript online:
20 June 2022
Article published online:
02 August 2022
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