Subscribe to RSS
DOI: 10.1055/a-1884-5723
Operativer und kathetergestützter Aortenklappenersatz – zwischen Evidenz und Empfehlung
Surgical and Transcatheter Aortic Valve Replacement – Between Evidence and RecommendationZusammenfassung
Patienten mit hochgradig symptomatischer Aortenklappenstenose haben unbehandelt eine reduzierte Lebenserwartung. Die operative und interventionelle Behandlung der Aortenklappe stehen als Behandlungsoptionen zur Verfügung. Entsprechend aktueller Leitlinien der EACTS/ESC und der DGTHG/DGK ist bei jüngeren Patienten mit niedrigem operativem Risiko weiterhin der operative Aortenklappenersatz (AKE) das Behandlungsverfahren der Wahl. Bei älteren Patienten bzw. Patienten mit erhöhtem operativem Risiko ist die interventionelle Aortenklappenimplantation (TAVI) die präferierte Methode. Im klinischen Alltag ist neben diesen Empfehlungen aber viel entscheidender, dass nach entsprechender Vordiagnostik unter Berücksichtigung der anatomischen Gegebenheiten, Komorbiditäten und individuellen Aspekten gemeinsam im Herzteam (repräsentiert durch eine/einen Herzchirurgen/in und interventionellen Kardiologen/in) mit dem Patienten eine optimale individuelle Entscheidung zur Behandlung getroffen wird.
Abstract
Untreated symptomatic severe aortic stenosis is associated with reduced survival. Surgical and interventional treatment is currently available. According to EACTS/ESC guidelines and DGTHG/DGK position paper surgical aortic valve replacement is the recommended treatment in younger patients with low surgical risk. Whereas in older patients or in patients with elevated surgical risk interventional aortic valve implantation (TAVI) should be preferred. In current clinical routine however, it is much more important to treat the patient based on an individualized decision considering various aspects (anatomic features, comorbidities, individual factors). This decision should be made by the heart team involving a cardiac surgeon and an interventional cardiologist in the context of “shared decision making”.
Als Behandlungsoptionen für Patienten mit hochgradig symptomatischer Aortenklappenstenose stehen der interventionelle (TAVI) bzw. chirurgische Aortenklappenersatz (AKE) zur Verfügung. Laut aktueller EACTS-ESC-Leitlinien ist für jüngere Patienten mit niedrigem OP-Risiko der AKE, für ältere Patienten mit erhöhtem OP-Risiko die TAVI die Behandlungsmethode der Wahl. Entscheidend ist jedoch hierbei, dass die individuelle optimale Entscheidung für die eine oder andere Methode im Heart Team unter Berücksichtigung anatomischer Gegebenheiten, Komorbiditäten, des Risikoprofils und auch des Patientenwunsches getroffen wird.
Publication History
Article published online:
05 October 2022
© 2022. Thieme. All rights reserved.
Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany
-
Literatur
- 1 Carroll JD, Mack MJ, Vemulapalli S. et al. STS-ACC TVT Registry of Transcatheter Aortic Valve Replacement. J Am Coll Cardiol 2020; 76: 2492-2516
- 2 Leon MB, Smith CR, Mack M. et al. Transcatheter aortic-valve implantation for aortic stenosis in patients who cannot undergo surgery. N Engl J Med 2010; 363: 1597-1607
- 3 Reardon MJ, Van Mieghem NM, Popma JJ. et al. Surgical or Transcatheter Aortic-Valve Replacement in Intermediate-Risk Patients. N Engl J Med 2017; 376: 1321-1331
- 4 Leon MB, Smith CR, Mack MJ. et al. Transcatheter or Surgical Aortic-Valve Replacement in Intermediate-Risk Patients. N Engl J Med 2016; 374: 1609-1620
- 5 Makkar RR, Thourani VH, Mack MJ. et al. Five-Year Outcomes of Transcatheter or Surgical Aortic-Valve Replacement. N Engl J Med 2020; 382: 799-809
- 6 Popma JJ, Deeb GM, Yakubov SJ. et al. Transcatheter Aortic-Valve Replacement with a Self-Expanding Valve in Low-Risk Patients. N Engl J Med 2019; 380: 1706-1715
- 7 Leon MB, Mack MJ, Hahn RT. et al. Outcomes 2 Years After Transcatheter Aortic Valve Replacement in Patients at Low Surgical Risk. J Am Coll Cardiol 2021; 77: 1149-1161
- 8 Jorgensen TH, Thyregod HGH, Ihlemann N. et al. Eight-year outcomes for patients with aortic valve stenosis at low surgical risk randomized to transcatheter vs. surgical aortic valve replacement. Eur Heart J 2021; 42: 2912-2919
- 9 Reardon MJ. Five-year incidence, outcomes, and predictors of structural valve deterioration of transcatheter and surgical aortic bioprostheses: insights from the CoreValve US Pivotal and SURTAVI trial. Washington DC: ACC Scientific Sessions; 2022
- 10 Beyersdorf F, Bauer T, Freemantle N. et al. Five-year outcome in 18 010 patients from the German Aortic Valve Registry. Eur J Cardiothorac Surg 2021; 60: 1139-1146
- 11 Seiffert M, Walther T, Hamm C. et al. The DEDICATE Trial: An independent all-comers trial of transcatheter aortic valve implantation vs. surgical aortic valve replacement in patients at low to intermediate operative risk is recruiting patients. Eur Heart J 2019; 40: 331-333
- 12 Nazif TM, Chen S, George I. et al. New-onset left bundle branch block after transcatheter aortic valve replacement is associated with adverse long-term clinical outcomes in intermediate-risk patients: an analysis from the PARTNER II trial. Eur Heart J 2019; 40: 2218-2227
- 13 Tamagnini G, Bourguignon T, Rega F. et al. Device profile of the Inspiris Resilia valve for aortic valve replacement: overview of its safety and efficacy. Expert Rev Med Devices 2021; 18: 239-244
- 14 Bilkhu R, Borger MA, Briffa NP. et al. Sutureless aortic valve prostheses. Heart 2019; 105: s16-s20
- 15 Diaz R, Hernandez-Vaquero D, Alvarez-Cabo R. et al. Long-term outcomes of mechanical versus biological aortic valve prosthesis: Systematic review and meta-analysis. J Thorac Cardiovasc Surg 2019; 158: 706-714.e18
- 16 Connolly SJ, Ezekowitz MD, Yusuf S. et al. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med 2009; 361: 1139-1151
- 17 Aboud A, Charitos EI, Fujita B. et al. Long-Term Outcomes of Patients Undergoing the Ross Procedure. J Am Coll Cardiol 2021; 77: 1412-1422
- 18 Horke A, Tudorache I, Laufer G. et al. Early results from a prospective, single-arm European trial on decellularized allografts for aortic valve replacement: the ARISE study and ARISE Registry data. Eur J Cardiothorac Surg 2020; 58: 1045-1053
- 19 Vahanian A, Beyersdorf F, Praz F. et al. 2021 ESC/EACTS Guidelines for the management of valvular heart disease. Eur Heart J 2022; 43: 561-632
- 20 Otto CM, Nishimura RA. Writing Committee Members. et al. 2020 ACC/AHA Guideline for the Management of Patients With Valvular Heart Disease: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. J Am Coll Cardiol 2021; 77: e25-e197
- 21 Kuck KH, Bleiziffer S, Eggebrecht H. et al. Consensus paper of the German Cardiac Society (DGK) and the German Society for Thoracic and Cardiovascular Surgery (DGTHG) on transcatheter aortic valve implantation (TAVI) 2020. Kardiologe 2020; 14: 182-204
- 22 Skaar E, Eide LSP, Norekval TM. et al. A novel geriatric assessment frailty score predicts 2-year mortality after transcatheter aortic valve implantation. Eur Heart J Qual Care Clin Outcomes 2019; 5: 153-160
- 23 Dent E, Martin FC, Bergman H. et al. Management of frailty: opportunities, challenges, and future directions. Lancet 2019; 394: 1376-1386