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DOI: 10.1055/a-1909-8220
Arteriosklerose, Cholesterinspiegel und sekundäre Pflanzenstoffe
Zusammenfassung
Seit langem wird ein erhöhter Cholesterinspiegel im Blut als Ursache für die Entstehung der Arteriosklerose postuliert und dementsprechend auch seine medikamentöse Senkung. Allerdings zeigt sich keine direkte Korrelation zwischen Cholesterinspiegel und kardiovaskulären Todesraten sowie dem Einsatz von Statinen. Verschiedene Prozesse bei der Arterioskleroseentstehung lassen sich jedoch durch Nahrungsmittel bzw. Mikronährstoffe beeinflussen. Protektive Wirkungen zeigen insb. sekundäre Pflanzenstoffe.
Schlüsselwörter
Arteriosklerose - Herz-Kreislauf-Erkrankungen - Cholesterinspiegel - Statinverbrauch - Arterioskleroseentstehung - oxidativer Stress - kardioprotektive Kost - sekundäre PflanzenstoffePublication History
Article published online:
05 October 2022
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Literatur
- 1 Anderson KM, Castelli WP, Levy D.. Cholesterol and mortality. 30 years of follow-up from the Framingham study. JAMA 1987; 257: 2176-2180
- 2 Wilkins E, Wilson L, Wickramasinghe K. et al. European Cardiovascular Disease Statistics 2017. European Heart Network, Brussels. 2017
- 3 Carroll MD, Lacher DA, Sorlie PD. et al. Trends in serum lipids and lipoproteins of adults, 1960–2002. JAMA 2005; 294: 1773-1781
- 4 Vancheri F.. Time Trends in statin utilization and coronary mortality in Western Europe Countries. BMJ Open 2016; 30: e010500
- 5 Mills EJ. Efficacy and safety of statin treatment for cardiovascular disease: a network meta-analysis of 170 255 patients from 76 randomized trials. Q J Med 2011; 104: 109-124
- 6 Baigent C. Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90 056 participants in 14 randomised trials of statins. Lancet 2005; 366: 1267-1278
- 7 Griendling KK, FitzGerald GA.. Oxidative stress and cardiovascular injury part 1: Basic mechanisms and in vivo monitoring of ROS. Circulation 2003; 108: 1912-1916
- 8 Estruch R, Martínez-González MA, Corella D. et al. Effects of a Mediterraneanstyle diet on cardiovascular risk factors: A randomized trial. Ann Intern Med 2006; 145: 1-11
- 9 Medina-Remón A.. Polyphenol intake from a Mediterranean diet decreases inflammatory biomarkers related to atherosclerosis: A substudy of the PREDIMED trial. Br J Clin Pharmacol 2017; 83: 114-128
- 10 Zordoky BN, Robertson IM, Dyck JR.. Preclinical and clinical evidence for the role of resveratrol in the treatment of cardiovascular diseases. Biochim Biophys Acta 2015; 1852: 1155-1177
- 11 Basu A, Du M, Leyva MJ. et al. Blueberries decrease cardiovascular risk factors in obese men and women with metabolic syndrome. J Nutr 2010; 140: 1582-1587
- 12 D’Andrea G.. Quercetin: a flavonol with multifaceted therapeutic applications?. Fitoterapia 2015; 106: 256-271
- 13 Dower JI, Geleijnse JM, Gijsbers L. et al. Supplementation of the pure flavonoids epicatechin and quercetin affects some biomarkers of endothelial dysfunction and inflammation in (Pre)hypertensive adults: a randomized double-blind, placebo-controlled, crossover trial. J Nutr 2015; 145: 1459-1463
- 14 Cheng HM, Koutsidis G, Lodge JK. et al. Tomato and lycopene supplementation and cardiovascular risk factors: A systematic review and meta-analysis. Atherosclerosis 2017; 257: 100-108
- 15 Bae YS, Lee JH, Choi SH. et al. Macrophages generate reactive oxygen species in response to minimally oxidized low-density lipoprotein: toll-like receptor 4–and spleen tyrosine kinase–dependent activation of NADPH oxidase 2. Circ Res 2009; 104: 210-218
- 16 González-Gallego J.. Fruit polyphenols immunity and inflammation. Br J Nutr 2010; 104: S15-S27