Synthesis 2023; 55(04): 637-646
DOI: 10.1055/a-1932-6146
paper

Room-Temperature, Transition-Metal-Free Arylation of Alcohols with Aryl Bromides

Da-Liang Zhu
a   School of Chemistry and Environmental Engineering, Analysis and Testing Centre, Yancheng Teachers University, Yancheng 224007, P. R. of China
b   College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P. R. of China
,
Jie Li
a   School of Chemistry and Environmental Engineering, Analysis and Testing Centre, Yancheng Teachers University, Yancheng 224007, P. R. of China
,
Qi Wu
b   College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P. R. of China
,
Yanqing Wang
a   School of Chemistry and Environmental Engineering, Analysis and Testing Centre, Yancheng Teachers University, Yancheng 224007, P. R. of China
,
c   College of Engineering, IT and Environment, Charles Darwin University, Darwin, NT 0909, Australia
,
Hong-Xi Li
b   College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P. R. of China
› Author Affiliations
The authors thank the National Natural Science Foundation of China (21971182, 21771131, and 22172138), the Priority Academic Program Development of Jiangsu Higher Education Institutions, Natural Science Foundation of the Jiangsu Higher Education Institutions (22KJB150048), and the Opening Project of Jiangsu Province Engineering­ Research Center of Agricultural Breeding Pollution Control and Resource (2021ABPCR005).


Abstract

Sodium tert-butoxide promotes the efficient etherification of alcohols with aryl bromides at room temperature. This simple procedure has a broad substrate scope, providing a practical pathway to aryl alkyl ethers in good yields without the addition of any transition metal species.

Supporting Information



Publication History

Received: 29 July 2022

Accepted after revision: 29 August 2022

Accepted Manuscript online:
29 August 2022

Article published online:
17 October 2022

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