Abstract
Background Diabetes mellitus is a highly prevalent condition that affects
people of all ages, races, and genders. Medicinal herbs have received a lot of
attention from researchers, and they have suggested it to be a good adjuvant to
oral diabetes medications because of their combined effects.
Objectives The purpose of this systematic review is to summarize the
available evidences and literature of Randomized Control Trials (RCTs) on
Nigella sativa (NS) in the management of Type 2 Diabetes Mellitus
(T2DM).
Methods A computerised database search was performed to obtain the
relevant clinical trial studies. We searched the following PubMed and Google
Scholar databases. Randomized controlled trials (RCTs) comparing NS versus any
treatment for the management of T2DM in adults were eligible for inclusion.
Results A total of 7 articles were retrieved for interpretation, complete
assessment and data extraction in this systematic review. This systematic review
seeks to give thorough information on the effects of NS on glucose and insulin
profile status in patients with T2DM.
Interpretation & Conclusion Different mechanisms are proposed
which contribute to the anti-diabetic activity of NS. Various outcome parameters
evaluated demonstrate a significant improvement in the management of T2DM and
its complications upon intervention with NS.
Key words
nigella sativa
- black cumin - kalonji - thymoquinone - type 2 diabetes mellitus - hypoglycaemia - blood glucose - fasting blood glucose - HbA1c
