Recent Developments in Solid-Phase Glycan Synthesis

Abstract

Solid-phase glycan synthesis (SPGS) is a valuable approach to access broad collections of complex, well-defined oligo- and polysaccharides in short amounts of time. The target structure is assembled following iterative cycles of glycosylation and deprotection, often aided by automated machines. To expand the scope of SPGS, new solid supports, linkers, glycosylation and deprotection reactions, and functionalization strategies are constantly being developed. Here we discuss the state of the art of SPGS, with particular focus on the chemistry happening on solid-phase. We highlight recent achievements as well as challenges to be addressed to expand the scope of SPGS even further.

1 Introduction

2 Solid-Phase Glycan Synthesis

2.1 The Solid Support

2.2 The Linker

2.3 The Assembly Process

2.4 Post-Assembly Manipulations

2.5 The Analysis

2.6 Cleavage from the Solid Support

3 Conclusion and Outlook

Key words

solid-phase synthesis - glycans - carbohydrates - automated glycan assembly

Publication History

Received: 14 July 2022

Accepted after revision: 07 September 2022

Accepted Manuscript online:
07 September 2022

Article published online:
18 October 2022

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